Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation Scott D Ross, MD, Curtis G Tribble, MD, John R Gaughen,

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Presentation transcript:

Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation Scott D Ross, MD, Curtis G Tribble, MD, John R Gaughen, BA, Kimberly S Shockey, MS, Patrick E Parrino, MD, Irving L Kron, MD The Annals of Thoracic Surgery Volume 67, Issue 5, Pages 1428-1433 (May 1999) DOI: 10.1016/S0003-4975(99)00248-9

Fig 1 Arterial oxygenation. Group III lungs displayed a progressive improvement in pO2 throughout reperfusion. ∗p= 0.005 (group III vs group II); ∗∗p = 0.01 (group III vs group II). The Annals of Thoracic Surgery 1999 67, 1428-1433DOI: (10.1016/S0003-4975(99)00248-9)

Fig 2 Pulmonary vascular resistance (PVR). Mean PVR in group III was significantly reduced when compared with control lungs. ∗p = 0.013; ∗∗p = 0.006; +p = 0.002; ++p = 0.003. The Annals of Thoracic Surgery 1999 67, 1428-1433DOI: (10.1016/S0003-4975(99)00248-9)

Fig 3 Microvascular permeability. EBD concentrations were significantly lower in group I control lungs after immediate reperfusion than in group II control lungs after ischemia and reperfusion. Leukocyte depletion in group III significantly reduced EBD when compared with group II. ∗p = 0.005 (vs group II). The Annals of Thoracic Surgery 1999 67, 1428-1433DOI: (10.1016/S0003-4975(99)00248-9)

Fig 4 Tissue MPO. MPO activity in group III was significantly lower than in group I and group II. ∗p = 0.002. The Annals of Thoracic Surgery 1999 67, 1428-1433DOI: (10.1016/S0003-4975(99)00248-9)

Fig 5 Light micrographs of lungs in group II and III. (A) Lungs in group II showed severe leukocyte infiltration and edema formation in the alveolar spaces. (B) In group III lungs, this infiltration was much lighter (H&E, magnification × 100). The Annals of Thoracic Surgery 1999 67, 1428-1433DOI: (10.1016/S0003-4975(99)00248-9)