Journal of Vascular Surgery

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Presentation transcript:

Journal of Vascular Surgery Vascular Cell Adhesion Molecule 1 Is a Promising Target to Identify High-Risk Carotid Plaques Using Contrast-Enhanced Duplex Ultrasound Craig C. Weinkauf, MD, PhD, Scott S. Berman, MD, MHA, Kay Goshima, MD, Luis R. Leon, MD, Edmund R. Marinelli, PhD, Rebecca Millius, MD, Evan C. Unger, MD Journal of Vascular Surgery Volume 64, Issue 2, (August 2016) DOI: 10.1016/j.jvs.2016.05.032 Copyright © 2016 Terms and Conditions

Fig 1 Carotid endarterectomy plaques have differential histology features. Formalin-fixed, decalcified carotid endarterectomy plaques were evaluated with trichrome staining by light microscopy (magnification ×10). Asymptomatic (A) plaques have low-risk features with uniform cholesterol-rich, calcified plaque (C). Symptomatic plaques (B) have a varying combination of high-risk features including lipid-rich necrotic core (D), inflammatory infiltrate (E), and intraplaque hemorrhage (F). L, Lumen. Journal of Vascular Surgery 2016 64, DOI: (10.1016/j.jvs.2016.05.032) Copyright © 2016 Terms and Conditions

Fig 2 V-CAM Selectively Stains High-Risk Carotid Plaques. IHC staining of 30 asymptomatic (A) and 30 symptomatic (S) CEA plaques with Anti-VCAM (1:200) were blindly graded on a 0-4 scale. Staining is seen best along the endothelium (arrows). Grade 0 = minimal staining; grade 4 = highest staining, see A1-A4. Symptomatic plaques had significantly higher VCAM staining (B) compared to asymptomatic plaques, of which 76.5% had low VCAM staining (C) as defined as grade 0 or 1. Journal of Vascular Surgery 2016 64, DOI: (10.1016/j.jvs.2016.05.032) Copyright © 2016 Terms and Conditions