Sporadic case of warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis syndrome Michael D. Tarzi, MD, Michael Jenner, PhD, Keith Hattotuwa,

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Presentation transcript:

Sporadic case of warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis syndrome Michael D. Tarzi, MD, Michael Jenner, PhD, Keith Hattotuwa, PhD, Asma Z. Faruqi, MD, George A. Diaz, PhD, Hilary J. Longhurst, PhD Journal of Allergy and Clinical Immunology Volume 116, Issue 5, Pages 1101-1105 (November 2005) DOI: 10.1016/j.jaci.2005.08.040 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 A, Vulval biopsy showing full-thickness epithelial dysplasia. There are numerous mitoses throughout the full thickness of the epithelium. B, Vulval biopsy from the same patient showing florid koilocytosis. Note perinuclear halos and large irregular nuclei (hematoxylin and eosin; original magnification ×200). Journal of Allergy and Clinical Immunology 2005 116, 1101-1105DOI: (10.1016/j.jaci.2005.08.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Myelokathexis cells. Bone marrow aspirate showing neutrophils with abnormal nuclei and very thin filaments connecting the nuclear lobes (May-Grunwald-Giemesa stain; original magnification ×800). Journal of Allergy and Clinical Immunology 2005 116, 1101-1105DOI: (10.1016/j.jaci.2005.08.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Mismatch PCR-RFLP assay for recurrent C1000→T mutation. Lanes: M, marker lane, 100-bp band indicated; 1, proband, BstUI digested amplicon; 2, wild-type control, BstUI digested amplicon; 3, C1000T control, BstUI digested amplicon; 4, undigested amplicon. Journal of Allergy and Clinical Immunology 2005 116, 1101-1105DOI: (10.1016/j.jaci.2005.08.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions