Predictors of Survival After Operation Among Patients With Large Cell Neuroendocrine Carcinoma of the Lung Florian Eichhorn, MD, Hendrik Dienemann, MD,

Slides:

Advertisements

Similar presentations

Jeffrey L. Port, MD, Robert J. Korst, MD, Paul C. Lee, MD, Amanda L

Advertisements

Lymphovascular Invasion as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Nathan M. Mollberg, DO,

Survival After Surgical Resection for Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease Anders Bugge, MD, May Brit Lund, MD, PhD, Cathrine.

Complete Thoracic Mediastinal Lymphadenectomy Leads to a Higher Rate of Pathologically Proven N2 Disease in Patients With Non-Small Cell Lung Cancer

Thomas J. Birdas, MD, Richard P. M

Preoperative Serum Fibrinogen Level Predicts Postoperative Pulmonary Complications After Lung Cancer Resection Suk-Won Song, MD, Hyun-Sung Lee, MD, Moon.

Melanie Subramanian, MD, Timothy McMurry, PhD, Bryan F

Sarcomatoid Carcinoma of the Lung: A Predictor of Poor Prognosis

Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.

Amiodarone Significantly Decreases Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer Lars P. Riber, MD, PhD, Thomas D. Christensen,

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD

Prognostic Factors Associated With Interventional Bronchoscopy in Lung Cancer Nicolas Guibert, MD, Julien Mazieres, MD, PhD, Benoît Lepage, MD, Gavin.

Lung Cancer Staging: A Case for a New T Definition

Morbidity, Survival, and Site of Recurrence After Mediastinal Lymph-Node Dissection Versus Systematic Sampling After Complete Resection for Non-Small.

Benjamin E. Lee, MD, Mark Shapiro, MD, John R. Rutledge, MAS, Robert J

Osteopontin Combined With CD44v6, a Novel Prognostic Biomarker in Non-Small Cell Lung Cancer Undergoing Curative Resection Bing-sheng Sun, MD, PhD, Yue.

Video-Assisted Thoracic Surgery Lobectomy: Experience With 1,100 Cases

Non-Small Cell Lung Cancer Resection in Lymphoma Patients

The Model for End-Stage Liver Disease (MELD) Predicts Early and Late Outcomes of Cardiovascular Operations in Patients With Liver Cirrhosis Naoto Morimoto,

Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival Yue Li, MD, Bing-sheng Sun, MD, PhD, Baoxiang Pei, MD, Chen-guang Li,

Importance of Ground Glass Opacity Component in Clinical Stage IA Radiologic Invasive Lung Cancer Aritoshi Hattori, MD, Takeshi Matsunaga, MD, Kazuya.

Prognostic Predictors in Non-Small Cell Lung Cancer Patients Undergoing Intentional Segmentectomy Terumoto Koike, MD, PhD, Teruaki Koike, MD, PhD, Yasushi.

Brendon M. Stiles, MD, Farooq Mirza, MD, Jeffrey L. Port, MD, Paul C

Michelle C. Ellis, MD, Brian S. Diggs, PhD, John T. Vetto, MD, Paul H

Expression of Bone Morphogenetic Proteins in Human Lung Carcinomas

Community-Based Multidisciplinary Computed Tomography Screening Program Improves Lung Cancer Survival Daniel L. Miller, MD, William R. Mayfield, MD,

Demographic, Psychosocial, and Behavioral Factors Associated With Survival After Heart Transplantation Steven A. Farmer, MD, PhD, Kathleen L. Grady,

Asad A. Shah, MD, Mathias Worni, MD, MHS, Christopher R

Thomas J. Birdas, MD, Richard P. M

Who Do You Say You Are? The Annals of Thoracic Surgery

Characteristics Associated With the Use of Nonanatomic Resections Among Medicare Patients Undergoing Resections of Early-Stage Lung Cancer Anthony W.

Influence of Cigarette Smoking on Survival and Tumor Invasiveness in Clinical Stage IA Lung Adenocarcinoma Ryo Maeda, MD, Junji Yoshida, MD, Genichiro.

Use of Amiodarone After Major Lung Resection

Clinical Significance of Tumor-Infiltrating Lymphocytes in Lung Neoplasms Enrico Ruffini, MD, Sofia Asioli, MD, Pier Luigi Filosso, MD, Paraskevas Lyberis,

A Pragmatic Approach to the Diagnosis of Nodal Micrometastases in Early Stage Non- small Cell Lung Cancer Esther Herpel, MD, Thomas Muley, PhD, Thomas.

Recurrence and Survival After Segmentectomy in Patients With Prior Lung Resection for Early-Stage Non-Small Cell Lung Cancer Lisa M. Brown, MD, Brian.

The Prognostic Value of the Number of Negative Lymph Nodes in Esophageal Cancer Patients After Transthoracic Resection Po-Kuei Hsu, MD, Chien-Sheng Huang,

Expression of vascular endothelial growth factor in thoracic sarcomas

Differences in Patterns of Recurrence in Early-Stage Versus Locally Advanced Non- Small Cell Lung Cancer Feiran Lou, MD, MS, Camelia S. Sima, MD, MS,

Matthew J. Bott, MD, Hanghang Wang, BA, William Travis, MD, Gregory J

Predictors of Long-Term Survival After Resection of Esophageal Carcinoma With Nonregional Nodal Metastases Paul C. Lee, MD, Jeffrey L. Port, MD, Subroto.

Surgical Therapy for Bilateral Multiple Primary Lung Cancer

Predictors of Nodal Metastases for Clinical T2N0 Esophageal Adenocarcinoma Arianna Barbetta, MD, Francisco Schlottmann, MD, Tamar Nobel, MD, David B.

Pulmonary Resection for Lung Cancer in Octogenarians

High Expression of p300 Has an Unfavorable Impact on Survival in Resectable Esophageal Squamous Cell Carcinoma Yong Li, MD, Hao-Xian Yang, MD, Rong-Zhen.

Selective Mediastinal Lymphadenectomy for Clinico-Surgical Stage I Non–Small Cell Lung Cancer Morihito Okada, MD, PhD, Toshihiko Sakamoto, MD, PhD, Tsuyoshi.

Clinicopathologic Features of Submucosal Esophageal Squamous Cell Carcinoma Manabu Emi, MD, PhD, Jun Hihara, MD, PhD, Yoichi Hamai, MD, PhD, Takaoki Furukawa,

Radiofrequency Ablation for Stage I Non-Small Cell Lung Cancer: Management of Locoregional Recurrence Michael Lanuti, MD, Amita Sharma, MD, Henning Willers,

Editorial Board, January 2010

Completely Thrombosed Tricuspid Pouch Mimicking a Cardiac Tumor

Arman Kilic, BS, Matthew J. Schuchert, MD, Brian L

Risk Factors for Local Recurrence and Optimal Length of Esophagectomy in Esophageal Squamous Cell Carcinoma Chang Hyun Kang, MD, PhD, Yoohwa Hwang, MD,

Shared Decision Making and Effective Risk Communication in the High-Risk Patient With Operable Stage I Non-Small Cell Lung Cancer Pamela Samson, MD,

Resected Synchronous Primary Malignant Lung Tumors: A Population-Based Study Hans Rostad, MD, PhD, Trond-Eirik Strand, MD, Anne Naalsund, MD, Jarle Norstein,

Treatment Outcomes of Patients With Different Subtypes of Large Cell Carcinoma of the Lung Yung-Han Sun, MS, Shih-Wei Lin, PhD, Chih-Cheng Hsieh, MD,

Modern Outcome and Risk Analysis of Surgically Resected Occult N2 Non-Small Cell Lung Cancer Hyun Jin Cho, MD, Sung Ryong Kim, MD, Hyeong Ryul Kim, MD,

Matthew J. Schuchert, MD, Omar Awais, DO, Ghulam Abbas, MD, Zachary D

Neoadjuvant and Adjuvant Chemotherapy in Resected Pulmonary Large Cell Neuroendocrine Carcinomas: A Single Institution Experience Inderpal S. Sarkaria,

Neal S Goldstein, MD The Annals of Thoracic Surgery

Pneumonectomy After Chemoradiation Therapy for Non-Small Cell Lung Cancer: Does “Side” Really Matter? Anthony W. Kim, MD, L. Penfield Faber, MD, William.

Effect of Formalin Fixation on Tumor Size Determination in Stage I Non-Small Cell Lung Cancer Po-Kuei Hsu, MD, Hsu-Chih Huang, MD, Chih-Cheng Hsieh,

Predictors of Pleural Implants in Patients With Thymic Tumors

Matthew J. Schuchert, MD, Brian L

Clinical Outcome After Pulmonary Resection for Lung Cancer Patients on Hemodialysis Toshiro Obuchi, MD, Wakako Hamanaka, MD, Yasuhiro Yoshida, MD, Jun.

Survival and Outcomes of Pulmonary Resection for Non-Small Cell Lung Cancer in the Elderly: A Nested Case-Control Study Robert J. Cerfolio, MD, Ayesha.

Mark I. Block, MD The Annals of Thoracic Surgery

Utilization and Outcomes of Unprotected Left Main Coronary Artery Stenting and Coronary Artery Bypass Graft Surgery Chuntao Wu, MD, PhD, Edward L. Hannan,

Domenico Galetta, MD, PhD, Lorenzo Spaggiari, MD, PhD

Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma Joachim Pfannschmidt, MD, Hans Hoffmann, MD, PhD, Thomas.

Long-Term Results of Sleeve Lobectomy in the Management of Non–Small Cell Lung Carcinoma and Low-Grade Neoplasms Robert E. Merritt, MD, Douglas J. Mathisen,

Presentation transcript:

Predictors of Survival After Operation Among Patients With Large Cell Neuroendocrine Carcinoma of the Lung Florian Eichhorn, MD, Hendrik Dienemann, MD, PhD, Thomas Muley, MD, Arne Warth, MD, Hans Hoffmann, MD, PhD The Annals of Thoracic Surgery Volume 99, Issue 3, Pages 983-989 (March 2015) DOI: 10.1016/j.athoracsur.2014.10.015 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Tumor-specific survival was 87%, 65%, and 55% after 1, 2, and 3 years, respectively. The Annals of Thoracic Surgery 2015 99, 983-989DOI: (10.1016/j.athoracsur.2014.10.015) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Higher stage of disease and (B) advanced nodal status had a significant influence on tumor-specific survival. The Annals of Thoracic Surgery 2015 99, 983-989DOI: (10.1016/j.athoracsur.2014.10.015) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Immunohistochemical analysis. Overall survival was not significantly influenced by single expression of (A) CD56 (p < 0.29), (B) chromogranin-A (CGA) (p < 0.42), (C) neuronal specific enolase (NSE) (p < 0.46), or (D) synaptophysin (SYN) (p < 0.45). The Annals of Thoracic Surgery 2015 99, 983-989DOI: (10.1016/j.athoracsur.2014.10.015) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Simultaneous expression of both CD56 and chromogranin-A (CGA) (p = 0.04) or one of each (p < 0.013) was associated with poorer outcome and higher risk of recurrence. The Annals of Thoracic Surgery 2015 99, 983-989DOI: (10.1016/j.athoracsur.2014.10.015) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions