The vascular secret of Klotho Ewa Lewin, Klaus Olgaard  Kidney International  Volume 87, Issue 6, Pages 1089-1091 (June 2015) DOI: 10.1038/ki.2015.80 Copyright © 2015 International Society of Nephrology Terms and Conditions

Figure 1 The vascular secrets of Klotho. Shown here are the three layers of aorta: the intima, the media, and the adventitia. The different effects of Klotho, either membrane bound or soluble, are indicated, but still marked with question marks, as the final settlement of the presence and potential effects of Klotho is still a matter of discussion. The reference to Klotho expression in the adventitia layer is based on the present report by Ritter et al.9 IGF, insulin-like growth factor; VSMC, vascular smooth muscle cell. Kidney International 2015 87, 1089-1091DOI: (10.1038/ki.2015.80) Copyright © 2015 International Society of Nephrology Terms and Conditions