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Volume 86, Issue 6, Pages 1221-1228 (December 2014) The body composition and excretory burden of lean, obese, and severely obese individuals has implications for the assessment of chronic kidney disease James Fotheringham, Nicholas Weatherley, Bisher Kawar, Damian G. Fogarty, Timothy Ellam Kidney International Volume 86, Issue 6, Pages 1221-1228 (December 2014) DOI: 10.1038/ki.2014.112 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Relationships between 24-h creatininuria and measures of obesity in the Chronic Renal Insufficiency Cohort (CRIC) Study. (a) Creatininuria versus body mass index (BMI); (b) creatininuria versus waist circumference; (c) creatininuria versus bioimpedance-estimated percentage fat mass. Graphs are truncated for presentation at BMI 55kg/m2 (excluding n=50 with more severe obesity) and waist circumference 150cm (excluding n=47) to avoid potentially misleading extrapolation through sparsely populated ranges. Kidney International 2014 86, 1221-1228DOI: (10.1038/ki.2014.112) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 The effects of obesity on estimated body surface area (BSA), creatinine excretion per m2 BSA, and the bias of estimated glomerular filtration rate (eGFR). Loess-smoothed plots of (a) estimated BSA versus body mass index (BMI), (b) creatininuria per m2 BSA versus BMI, (c) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR bias versus BMI, (d) CKD-EPI eGFR bias versus waist circumference, (e) CKD-EPI eGFR bias versus bioimpedance-estimated percentage fat mass, (f) MDRD eGFR bias versus BMI. Curves are truncated for presentation at BMI 50kg/m2 (excluding n=12 with more severe obesity in the subcohort with iothalamate-measured glomerular filtration rate (iGFR) measurements) and waist circumference 150cm (excluding n=7) to avoid potentially misleading extrapolation through sparsely populated ranges. MDRD, Modification of Diet in Renal Disease. Kidney International 2014 86, 1221-1228DOI: (10.1038/ki.2014.112) Copyright © 2014 International Society of Nephrology Terms and Conditions