Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery F Weis, A Beiras-Fernandez, D Hauer,

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Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery F Weis, A Beiras-Fernandez, D Hauer, C Hornuss, R Sodian, S Kreth, J Briegel, G Schelling British Journal of Anaesthesia Volume 105, Issue 2, Pages 139-144 (August 2010) DOI: 10.1093/bja/aeq117 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Changes in plasma concentrations of the endocannabinoids AEA and 2-AG before, during and after CS. Data presented as mean (sem). Preop, measurements in the awake patient before induction of anaesthesia; Anaesthesia, after induction of anaesthesia but before surgery; Surgery, measurements during surgery (sternotomy); Intra-CPB, during CPB; Post-CPB, after termination of CPB; ICU, values at admission to the cardiovascular ICU. *Significantly higher AEA plasma concentrations in the awake patient before induction of anaesthesia when compared with all other time points (unadjusted P<0.001, critical level=0.010, one-way rm-anova with the Holm–Sidak post hoc test). #Significantly higher 2-AG plasma concentrations during surgery and CPB compared with baseline values in the awake state (unadjusted P≤0.002, critical level ≤0.013). British Journal of Anaesthesia 2010 105, 139-144DOI: (10.1093/bja/aeq117) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Correlation between preoperative plasma anandamide concentrations and patients’ BMI. Preoperative plasma AEA concentrations correlated positively with the patients’ preoperative BMI (r=0.43; P=0.02). British Journal of Anaesthesia 2010 105, 139-144DOI: (10.1093/bja/aeq117) Copyright © 2010 The Author(s) Terms and Conditions