Selective IgA deficiency in humans is associated with reduced gut microbial diversity Silje Fjellgård Jørgensen, MD, PhD, Kristian Holm, MSc, Magnhild.

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Selective IgA deficiency in humans is associated with reduced gut microbial diversity Silje Fjellgård Jørgensen, MD, PhD, Kristian Holm, MSc, Magnhild Eide Macpherson, MD, Christopher Storm-Larsen, Martin Kummen, MD, PhD, Børre Fevang, MD, PhD, Pål Aukrust, MD, PhD, Johannes Roksund Hov, MD, PhD Journal of Allergy and Clinical Immunology Volume 143, Issue 5, Pages 1969-1971.e11 (May 2019) DOI: 10.1016/j.jaci.2019.01.019 Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Low intraindividual microbial diversity in patients with SIgAD, which does not correlate with the number of courses of antibiotics in the last year. A, Alpha diversity (Chao1) in patients with SIgAD, patients with CVID, and controls. The comparison is made by Mann-Whitney U test, and significant P value is marked as ***P < .001. B, Scatterplot comparing the number of courses of antibiotics in the last year (excluding the last month) versus alpha diversity, Chao1. Rho: Spearman rank correlation coefficient. ∗Excluding the last month. Journal of Allergy and Clinical Immunology 2019 143, 1969-1971.e11DOI: (10.1016/j.jaci.2019.01.019) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flowchart of inclusion/exclusion of patients with SIgAD in the study. *The patient had a severe intellectual disability as well as a physical disability, which may be associated with a monogenic disease/syndrome not yet classified. The individual was therefore excluded from the study. †At the time of the end of study analysis (2018), the patient had normalized serum IgA levels. Although not recognized at the time of screening, the previous serum IgA deficiency was likely secondary to the neuroleptica the patient used at the time of screening. After stopping neuroleptica, the serum IgA levels normalized. Journal of Allergy and Clinical Immunology 2019 143, 1969-1971.e11DOI: (10.1016/j.jaci.2019.01.019) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Flowchart of inclusion/exclusion of patients with CVID in the study. Journal of Allergy and Clinical Immunology 2019 143, 1969-1971.e11DOI: (10.1016/j.jaci.2019.01.019) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Alpha diversity (Chao1) in SIgAD for different diets (A) and clinical phenotype (B). Journal of Allergy and Clinical Immunology 2019 143, 1969-1971.e11DOI: (10.1016/j.jaci.2019.01.019) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Alpha diversity (Chao1) in CVID separated by enteropathy. Alpha diversity (Chao1) comparing CVID with and without enteropathy. Shown in median and quartiles. The comparisons are made by Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2019 143, 1969-1971.e11DOI: (10.1016/j.jaci.2019.01.019) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Alpha diversity (Chao1) in CVID separated by IgA levels. Alpha diversity (Chao1) comparing CVID with serum IgA levels of less than 0.1 g/L versus CVID with IgA levels of greater than or equal to 0.1 g/L. Shown in median, quartiles, and range. The comparisons are made by Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2019 143, 1969-1971.e11DOI: (10.1016/j.jaci.2019.01.019) Copyright © 2019 American Academy of Allergy, Asthma & Immunology Terms and Conditions