Spironolactone alleviates late cardiac remodeling after left ventricular restoration surgery Masaki Tsukashita, MD, Akira Marui, MD, PhD, Takeshi Nishina,

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Presentation transcript:

Spironolactone alleviates late cardiac remodeling after left ventricular restoration surgery Masaki Tsukashita, MD, Akira Marui, MD, PhD, Takeshi Nishina, MD, PhD, Eiji Yoshikawa, MD, Hideo Kanemitsu, MD, PhD, Jian Wang, MD, Tadashi Ikeda, MD, PhD, Masashi Komeda, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 136, Issue 1, Pages 58-64 (July 2008) DOI: 10.1016/j.jtcvs.2007.11.016 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The time course of FAC calculated from the echocardiographic data obtained from LVR (closed circles) and LVR-Sp (closed squares) groups. ∗P < .05 versus LVR. Values are represented as mean ± standard deviation. LVR, Left ventricular restoration; LVR-Sp, left ventricular restoration with spironolactone. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 58-64DOI: (10.1016/j.jtcvs.2007.11.016) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 LV weight (A) and lung weight (B) normalized to the BW (gray bar: LVR group, white bar: LVR-Sp group). †P < .05 versus LVR. Values are represented as mean ± standard deviation. LV, left ventricular; LVR, left ventricular restoration; LVR-Sp, left ventricular restoration with spironolactone. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 58-64DOI: (10.1016/j.jtcvs.2007.11.016) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Histologic findings. High-power photomicrographs (×200) of Picrosirius red-stained LV cross-section obtained from LVR (A) and LVR-Sp (B) rats. In the LVR group, the interstitial fibrosis (arrows) partially forms a reticular structure surrounding the myocardial fibers. In the LVR-Sp group, the fibrosis is thin and scatters among the myocardial fibers. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 58-64DOI: (10.1016/j.jtcvs.2007.11.016) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Low-power photomicrographs (×40) of Picrosirius red-stained LV cross-section obtained from LVR (A) and LVR-Sp (B) groups. Dense collagen fiber (arrows) develops around the pledgets (asterisks) in the LVR group. Spironolactone attenuated fibrous accumulation. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 58-64DOI: (10.1016/j.jtcvs.2007.11.016) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Myocardial expression of BNP mRNA (A) and TGF-β1 mRNA (B) in the LVR and LVR-Sp groups 4 weeks after LVR. Data are normalized to the GAPDH expression. †P < .05 vs LVR. ‡P < .01 versus LVR. Values are represented as mean ± standard deviation. BNP, Brain natriuretic peptide; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; TGF, transforming growth factor; LVR, left ventricular restoration; LVR-Sp, left ventricular restoration with spironolactone. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 58-64DOI: (10.1016/j.jtcvs.2007.11.016) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions