Role of cytokines in endometriosis

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Role of cytokines in endometriosis Tasuku Harada, M.D., Tomio Iwabe, M.D., Naoki Terakawa, M.D. Fertility and Sterility Volume 76, Issue 1, Pages 1-10 (July 2001) DOI: 10.1016/S0015-0282(01)01816-7

Figure 1 Factors involved in the pathogenesis of endometriosis. Harada. Role of cytokines in edometriosis. Fertil Steril 2001. Fertility and Sterility 2001 76, 1-10DOI: (10.1016/S0015-0282(01)01816-7)

Figure 2 Reverse transcriptase polymerase chain reaction determination of interleukin (IL)-8 receptor messenger RNA expression in endometrial and endometriotic stromal cells. (A), Ethidium bromide-stained agarose gel analysis of the amplified products. Lanes 1 and 3 are endometrial stromal cells; lanes 2 and 4 are endometriotic stromal cells. HaeIII-digested X174 size markers were used in the left lane (lane M). (B), The specificity of polymerase chain reaction products was confirmed by hybridization of oligonucleotide probe. Lane 1 is endometrial stromal cells, and lane 2 is endometriotic stromal cells. Glycerol-3-phosphate dehydrogenase (G3PDH) was used as a positive control. Harada. Role of cytokines in edometriosis. Fertil Steril 2001. Fertility and Sterility 2001 76, 1-10DOI: (10.1016/S0015-0282(01)01816-7)

Figure 3 Reverse transcriptase polymerase chain reaction revealed tumor necrosis factor receptor (TNFR)-I and -II messenger RNA expression in endometriotic cells. The U937 cell lines (lymphoma) were used as a positive control for tumor necrosis factor receptors. Lane 1 is U937 cells, lane 2 is endometriotic stromal cells, and lane 3 is reverse transcriptase (−). Glycerol-3-phosphate dehydrogenase (G3PDH) was used as a positive control (data not shown). Harada. Role of cytokines in edometriosis. Fertil Steril 2001. Fertility and Sterility 2001 76, 1-10DOI: (10.1016/S0015-0282(01)01816-7)

Figure 4 The role of peritoneal fluid and cytokines in the pathophysiology of endometriosis-associated infertility. Accumulated data suggested that substances found in the peritoneal fluid of patients with endometriosis contribute to infertility by impairing embryo development, egg penetration by sperm, and sperm function. Harada. Role of cytokines in edometriosis. Fertil Steril 2001. Fertility and Sterility 2001 76, 1-10DOI: (10.1016/S0015-0282(01)01816-7)