Exosomes transfected with obesity-associated miRNAs induce glucose intolerance dissociated from obesity. Exosomes transfected with obesity-associated miRNAs.

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Exosomes transfected with obesity-associated miRNAs induce glucose intolerance dissociated from obesity. Exosomes transfected with obesity-associated miRNAs induce glucose intolerance dissociated from obesity. (A and B) Plasma TG (A) and FFA (B) concentrations from chow-fed mice after 4 wk of injections of exosomes loaded with mimics of four miRNAs enriched in obese exosomes. (C and D) IpGTT (C) and insulin tolerance test (0.175 U/kg) (D) in mice described in A and B. (E and F) Correlation between the glycemia AUC obtained from the IpGTT and either body weight (E) or percentage of eWAT (F). Data are presented as mean ± SEM. n = 5 per group (A–F). *P < 0.05, **P < 0.01, Student’s t test. Carlos Castaño et al. PNAS 2018;115:48:12158-12163 ©2018 by National Academy of Sciences