What’s All The Buzz About B’s? Activated B-Complex What’s All The Buzz About B’s?

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

B Vitamins: Basics, Functions and Benefits Water-soluble Play roles as co-enzymes in the metabolism of protein, fat and carbohydrates Support a healthy rate of metabolism Help maintain healthy skin and muscle Support immune and nervous system functions Promote normal cell growth and division Promotes energy Promotes a healthy mental outlook, mood, memory Supports a healthy heart system

B Vitamins Vitamin B1 (Thiamin) Vitamin B2 (Riboflavin) Vitamin B3 (Niacin) Vitamin B5 (Pantothenate) Vitamin B6 (Pyridoxine) Vitamin B7 (Biotin) Vitamin B9 (Folic Acid) Vitamin B12 (Cobalamin)

Advanced B-Complex Vs Activated B-Complex Pyridoxal-5-Phosphate → Pyridoxal-5-Phosphate Folic Acid → Folinic Acid Cyanocobalamin → Methylcobalamin

Vitamin B6 (Pyridoxal-5-Phosphate) Presently in Advanced B-Complex Pyridoxal-5-phosphate (P5P) is the main biologically active form of vitamin B6 Does not require activation by the liver

Pyridoxal-5-Phosphate: Physiological Functions Supports numerous processes in the body Catalyzes reactions involving amino acids (> 100 enzymes need) Metabolism and usage of amino acids Red blood cell metabolism and heme biosynthesis Conversion of homocysteine to cysteine Conversion of tryptophan to niacin Involved in the synthesis of neurotransmitters in the brain and peripheral nerve cells

Pyridoxal-5-Phosphate: Research Supplementation helps to correct vitamin B6 deficiency Deficient levels of plasma P5P associated with: Impaired amino acid enzyme activity Neurological and mental performance Higher plasma C-reactive protein (CRP) levels, oxidative stress, homocysteine, metabolic conditions Heart health

folate → dihydrofolate → tetrahydrofolate ↔ methylene-THF → methyl-THF Folinic acid Folinic acid is a highly bioavailable metabolically active derivative of folic acid that can be readily converted into other reduced folic acid derivatives folate → dihydrofolate → tetrahydrofolate ↔ methylene-THF → methyl-THF Does not require dihydrofolate reductase to become active so not affected by medicines and herbs that inhibit this enzyme Inhibition of enzyme can result in folic acid deficiency Provides all vitamin activity equivalent to folic acid

Folic Acid: Physiological Functions Support numerous processes in the body DNA synthesis, repair, and methylation Cell synthesis, maturation, and division Especially important during fetal growth and for the production of red blood cells Proper development of the nervous system Per the FDA healthful diets containing adequate folate may reduce a woman’s risk of having a child with a brain or spinal cord defect Regulation of homocysteine levels Production of neurotransmitters and for healthy neurological functions Deficiency implicated in the deterioration of memory and cognitive function associated with the aging process Supports conversion of sulfur-containing compounds to glutathione

Folic Acid and MTHFR Genetic variants in the MTHFR gene have a reduced methylenetetrahydrofolate reductase (enzyme) activity which can inhibit the levels of activated folic acid available These variations have been linked to increased homocysteine levels which can effect heart health Folinic acid, unlike folic acid, does not require the action of the enzyme MTHFR Many metabolic processes can occur in the presence of MTHFR associated polymorphisms which may otherwise be inhibited

Methylcobalamin (Vitamin B12) Methylcobalamin is a highly bioavailable metabolically active form of B12 (cobalamin). Methylcobalamin and 5-deoxyadenosylcobalmin are the active forms of B12 used by the body Cyanocobalamin is a synthetic form often used in supplements Primary form used in treating B12 deficiency Deficiencies can occur due to age, reduced ability to produce intrinsic factor, veganism, medications

Methylcobalamin: Physiological Functions Supports numerous processes in the body Transfer of methyl groups; necessary for methylation reactions DNA synthesis and regulation Cell synthesis, maturation and division Especially important for the normal production of red blood cells Conversion of homocysteine to methionine Proper functioning of the nervous system Methionine is necessary for the normal synthesis of myelin sheaths Metabolism and utilization of carbohydrates, proteins and fats Fatty acid synthesis and energy production Production of SAMe (S-adenosyl-L-methionine)

Methylcobalamin and MTR Genetic variation in the methionine synthase (MTR) gene appears to result in increased enzyme activity. This variation appears to have a positive effect on homocysteine levels. Methylcobalamin is the specific form of B12 MTR uses as a co-enzyme in the conversion of homocysteine to methionine Variants and non variants will benefit from use

Activated B-Complex 100 g MA Code: 13055 nutraMetrix: 13967 DC: $17.00 SR: $22.50 BV: 13

Activated B-Complex 300 g MA Code: 13057 nutraMetrix: 13965 DC: $39.00 SR: $49.95 BV: 30

Thank You and Good Night