pkd1a/b and pkd2 interact in axial morphogenesis. pkd1a/b and pkd2 interact in axial morphogenesis. Top panels: the range of severity in dorsal axis curvature that was used for scoring. Mild: <90 degrees; moderate >90 degrees; severe: tail tip crossing the body axis. The chart represents the percentage of embryos with mild, moderate or severe curvature; the knockdown conditions were as noted in the legend. The data represent the averages of three separate experiments; error bars represent standard error of the mean (s.e.m.). Steve Mangos et al. Dis. Model. Mech. 2010;3:354-365 ©2010 by The Company of Biologists Limited