Clinical and Translational Radiation Oncology

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Presentation transcript:

Clinical and Translational Radiation Oncology Prospective in silico study of the feasibility and dosimetric advantages of MRI-guided dose adaptation for human papillomavirus positive oropharyngeal cancer patients compared with standard IMRT Abdallah S.R. Mohamed, Houda Bahig, Michalis Aristophanous, Pierre Blanchard, Mona Kamal, Yao Ding, Carlos E. Cardenas, Kristy K. Brock, Stephen Y. Lai, Katherine A. Hutcheson, Jack Phan, Jihong Wang, Geoffrey Ibbott, Refaat E. Gabr, Ponnada A. Narayana, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Clifton D. Fuller Clinical and Translational Radiation Oncology Volume 11, Pages 11-18 (June 2018) DOI: 10.1016/j.ctro.2018.04.005 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Schema of in silico adaptive planning protocol. Clinical and Translational Radiation Oncology 2018 11, 11-18DOI: (10.1016/j.ctro.2018.04.005) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Adaptive dose reduction workflow shown on the left; as GTV (green) shrinks, so does the high dose (CTV 2.12 Gy/day region) which become included in the low dose target (CTV 1.52 Gy/day region). Standard radiotherapy doses are shown on the right. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Clinical and Translational Radiation Oncology 2018 11, 11-18DOI: (10.1016/j.ctro.2018.04.005) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Details of volumetric response of target volumes for all patients at each time point, over the course of therapy. Patient 2 had an excisional biopsy prior to definitive IMRT and, therefore, had no GTVn at radiation start. Clinical and Translational Radiation Oncology 2018 11, 11-18DOI: (10.1016/j.ctro.2018.04.005) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 Boxplots depicting the comparison of normal tissue complication probability (NTCP) between standard and adaptive methods. Clinical and Translational Radiation Oncology 2018 11, 11-18DOI: (10.1016/j.ctro.2018.04.005) Copyright © 2018 The Authors Terms and Conditions