Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury Zhengyu Luo, Maurizio Diaco, Toyoaki Murohara, Napoleone Ferrara,

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Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury Zhengyu Luo, Maurizio Diaco, Toyoaki Murohara, Napoleone Ferrara, Jeffrey M Isner, James F Symes The Annals of Thoracic Surgery Volume 64, Issue 4, Pages 993-998 (October 1997) DOI: 10.1016/S0003-4975(97)00715-7

Fig. 1 The hearts were perfused in the nonworking mode for 5 minutes. Baseline measurements were obtained at 10 and 20 minutes after converting hearts to the working mode. Cardioplegic solution (see Table 1) was infused at 0, 30, 60, and 90 minutes of global ischemia. At the end of global ischemia, the hearts were reperfused in the nonworking mode for 10 minutes and in the working mode for an additional 30 minutes. Postischemic creatine kinase (CK) release was measured in the nonworking mode, and hemodynamics were measured at 20 and 30 minutes of reperfusion. The Annals of Thoracic Surgery 1997 64, 993-998DOI: (10.1016/S0003-4975(97)00715-7)

Fig. 2 Percent recovery of (a) coronary flow (CF), (b) cardiac output (CO), and (c) stroke work (SW). Values are shown as mean ± standard error of the mean. (l-NAME = Nω-nitro-l-arginine methyl ester; VEGF = vascular endothelial growth factor; ∗p < 0.05 versus control.) The Annals of Thoracic Surgery 1997 64, 993-998DOI: (10.1016/S0003-4975(97)00715-7)

Fig. 3 Percent of coronary vascular resistance (CVR) after ischemia-reperfusion. Values are shown as mean ± standard error of the mean. (l-NAME = Nω-nitro-l-arginine methyl ester; VEGF = vascular endothelial growth factor; ∗p < 0.05 versus control.) The Annals of Thoracic Surgery 1997 64, 993-998DOI: (10.1016/S0003-4975(97)00715-7)

Fig. 4 Creatinine kinase (CK) release after ischemia-reperfusion. Values are presented as mean ± standard error of the mean; (l-NAME = Nω-nitro-l-arginine methyl ester; VEGF = vascular endothelial growth factor; ∗p < 0.05 versus control.) The Annals of Thoracic Surgery 1997 64, 993-998DOI: (10.1016/S0003-4975(97)00715-7)