The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy Kamal D. Srivastava, MPhil, Jacob.

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The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy Kamal D. Srivastava, MPhil, Jacob D. Kattan, BS, Zhong Mei Zou, PhD, Jing Hua Li, MD, Libang Zhang, MD, Sylvan Wallenstein, PhD, Joseph Goldfarb, PhD, Hugh A. Sampson, MD, Xiu-Min Li, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 1, Pages 171-178 (January 2005) DOI: 10.1016/j.jaci.2004.10.003 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 A, FAHF-2 prevented a drop in core body temperatures. Rectal temperatures were measured 25 minutes after intragastric peanut challenge in mice challenged at weeks 10 (○), 12 (▿), and 14 (□). Bars indicate the medians of temperature from totals of 5 sets of experiments (sham, n=38; FAHF-2, n=26; naive, n=29). §P < .001 vs naive; ‡P < .001 vs sham. B, FAHF-2 blocked histamine release. Data are plasma histamine levels 30 minutes postchallenge for the same mice as in A. §P < .001 vs naive; ‡P < .001 vs sham. Journal of Allergy and Clinical Immunology 2005 115, 171-178DOI: (10.1016/j.jaci.2004.10.003) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 FAHF-2 prevented vascular leakage. Photograph illustrates mouse footpads after Evan's blue /peanut administration at week 14. Marked vascular leakage (blue) is seen in the sham-treated mice but not in FAHF-2–treated and naive mice. Results represent 2 to 3 mice from each group. Journal of Allergy and Clinical Immunology 2005 115, 171-178DOI: (10.1016/j.jaci.2004.10.003) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Effect of FAHF-2 on serum peanut-specific IgE and IgG2a levels. Sera were obtained 1 day before treatment (week 3), at each boosting (weeks 6 and 8), and 1 and 5 weeks posttherapy (weeks 10 and 14) in week 14 challenge experiments. Serum peanut-specific IgE (A) and IgG2a (B) levels were determined by ELISA. Data are means ± SEMs for each group from 3 sets of week 14 challenge experiments (sham, n=21; FAHF-2, n=13; naive, n=15). ‡P < .001 vs sham. Journal of Allergy and Clinical Immunology 2005 115, 171-178DOI: (10.1016/j.jaci.2004.10.003) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Cytokine levels in splenocyte culture supernatants. Splenocytes were pooled from each group after week 14 challenge. Results are expressed as means ± SEMs of cytokines for 3 sets of week 14 challenge experiments. †P < .01 and ‡P < .001 vs sham. PN, Crude peanut extract; Med, medium. Journal of Allergy and Clinical Immunology 2005 115, 171-178DOI: (10.1016/j.jaci.2004.10.003) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions