Fig. 5 Putative latency-reversing agents exert differential effects on the different blocks to HIV transcription. Putative latency-reversing agents exert.

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Fig. 5 Putative latency-reversing agents exert differential effects on the different blocks to HIV transcription. Putative latency-reversing agents exert differential effects on the different blocks to HIV transcription. (A to E) Total CD4+ T cells from five ART-suppressed HIV-infected individuals (A to E) were divided into aliquots of 5 × 106 cells and cultured for 24 hours with dimethyl sulfoxide (DMSO) (negative control), different latency-reversing agents, or anti-CD3/CD28 antibody-coated beads. Latency-reversing agents were used at concentrations that can be obtained in the plasma or those used in previous ex vivo studies. After 24 hours, cells were harvested from each well and used to measure read-through (orange), total (pink), elongated (green), polyadenylated (blue), and multiply spliced Tat-Rev (red) HIV transcripts using RT-ddPCR. Amounts of each transcript were divided by those in the negative control (DMSO) well to show the fold change (y axis) in each transcript (different colors) for each latency-reversing agent or control on the x axis. Ingenol 3,20, ingenol 3,20-dibenzoate; PEP005, ingenol mebutate (ingenol-3-angelate). Steven A. Yukl et al., Sci Transl Med 2018;10:eaap9927 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works