mTOR downregulation, but not autophagy, reduces VAP(P58S) aggregation.

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mTOR downregulation, but not autophagy, reduces VAP(P58S) aggregation. mTOR downregulation, but not autophagy, reduces VAP(P58S) aggregation. (A-C) Rapamycin feeding decreases aggregation density in the ventral nerve cord of third-instar larval brains in C155-GAL4/+; UAS-VAP(P58S)/+ flies. (D-F) Neuronal Tor knockdown decreases aggregation density in the ventral nerve cord. The ‘_i ’ appended to a gene name indicates an RNAi line. (G-I) Neuronal overexpression of Atg1 did not affect the aggregation density in the ventral nerve cord. All images were taken at the same magnification. Student's t-test (**P<0.01; ns, not significant). (J) Model depicting mTOR-regulated clearance of aggregates, independent of autophagy. Error bars indicate s.d. Kriti Chaplot et al. Dis. Model. Mech. 2019;12:dmm033803 © 2019. Published by The Company of Biologists Ltd