Nat. Rev. Neurol. doi: /nrneurol

Slides:

Advertisements

Similar presentations

NERVOUS TISSUE.

Advertisements

Mind, Brain & Behavior Monday January 13, Interview with Rodney Brooks Human as machine, machine as human:

The Nervous System- Nervous Tissue Chapter 13

Nonneuronal Cells of the Nervous System Melissa Metzler.

Lecture 12a. Nervous System Overview. Topics Divisions of the NS: CNS and PNS Structure and types of neurons Synapses Structure and function of glia in.

The Nervous System: Neural Tissue Chapter 13. Human Anatomy, 3rd edition Prentice Hall, © 2001 Introduction Nervous system = control center & communications.

Chapter 8.2: The Nervous System. Neuroglia  Astrocytes  Largest and most numerous  Maintain blood-brain barrier  Isolates CNS from circulation  Capillaries.

Fundamentals of the Nervous System and Nervous Tissue

HISTOLOGY 1.14.: NERVOUS TISSUE: GLIAL CELLS

Nervous Tissue. Neuroglia “Nerve Glue” (Support Cells) Neuroglia - nonconductiong cells that provide protection & support and assist with metabolism.

Other Nerve Impulse Neuron Structure Neuroglia Organization

Nervous Tissue 2 Originally Given By: Dr.Ahmed Attayeb Written By: Dr.Divine, Edited & Made up 2 date: Abo Malik Thanks for: DR.I.

Biomarkers for Concussion Detection Jillian Holden BME 281 November 3, 2015.

The Nervous System maintains homeostasis and responds to stimuli faster than any other system! Part A. Organization Part B. Neural Tissue Chapter 12 Organization.

Histology of Nervous Tissue

A. providing sensation of the internal and external environments B. integrating sensory information C. coordinating voluntary and involuntary activities.

The Nervous System: Neural Tissue Chapter 13. Human Anatomy, 3rd edition Prentice Hall, © 2001 Introduction Nervous system = control center & communications.

Non-Neuronal Cells of the Nervous System Neuroglia Can’t generate or transmit nerve impulses (signals)

Neurons, nerves and glia Lucija Milošević 2nd year University of Zagreb, School of Medicine 2013/14 Mentor: A. Žmegač Horvat.

9 Unit 1 Chapter 9. 9 Unit 1 Brain- Neurons enclosed in skull Spinal cord– connects to brain & enclosed in spinal cavity Nerves- bundles of neuronal axons.

Nervous System. Functions of the Nervous System Monitor internal and external environments Integrate sensory information Coordinate voluntary and involuntary.

Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Blood Biomarkers for Brain Injury in Concussed Professional.

Microscopic Structure of the CNS

Volume 15, Issue 7, Pages (June 2016)

The Nervous System- Nervous Tissue Chapter 13

Nat. Rev. Neurol. doi:10/1038/nrneurol

Introduction to the Nervous System and Nerve Tissue

Introduction to Nervous System.

Prolonged Repetitive Head Trauma Induces a Singular Chronic Traumatic Encephalopathy–Like Pathology in White Matter Despite Transient Behavioral Abnormalities

Volume 3, Issue 2, Pages (June 2017)

The Nervous System Mr. Nichols

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 The US Centers for Disease Control and

Figure 4 Cerebrospinal fluid levels of neurofilament light chain

Figure Model contrasting the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG) or aquaporin-4 (AQP4) in opticospinal inflammationMOG-specific.

Figure 2 Monoamine synthesis and metabolism in neurons

Nat. Rev. Neurol. doi: /nrneurol

Neuronal and glial CSF biomarkers in patients with secondary progressive multiple sclerosis treated with dimethyl fumarate Keith R. Edwards1 , Jessica.

Nat. Rev. Neurol. doi: /nrneurol

Nervous System.

Figure 5 Interactions between neurons, glial cells and cancer cells

Figure 4 Neuromyelitis optica spectrum disorder brain lesions

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Physiological metabolism of Aβ in the brain and periphery

Figure 1 Schematic overview of the LGI1 protein in the synapse

Figure 1 Clinical correlates of neurodegeneration in MS

Figure 4 Generation of tau seeds and spread of tau pathology

Cerebrospinal Fluid Markers of Brain Injury, Inflammation, and Blood-Brain Barrier Dysfunction in Cardiac Surgery Björn Reinsfelt, MD, PhD, Sven-Erik.

Nat. Rev. Neurol. doi: /nrneurol

Figure 6 Vascular dysfunction in epilepsy

Figure 3 VEGF in neurodegenerative disease

Figure 3 Current model of immunopathogenesis in CIDP

Figure 1 Key events in the pathophysiological cascade of MSA

Figure 1 Biomarkers associated with different clinical phases in MS

Figure 2 Brain biopsy Brain biopsy (A) Double staining with anti-aquaporin-4 (AQP4) antibody (dark green) and Luxol fast blue (blue) is shown. Loss of.

Figure 1 Tau PET images in patients with Alzheimer disease

Volume 91, Issue 1, Pages 1-3 (July 2016)

Figure 4 Representative images of skin biopsy sample

Endocrine System Nervous System

Figure 7 VEGF as a mediator of neuroinflammatory disease

Figure 3 Blood–brain barrier breakdown promotes neurodegeneration

Figure 4 Autopsy immunochemistry results

Minocycline prevents osmotic demyelination associated with aquaresis

Figure 2 Hypothetical model of temporal brain changes

Figure 1. Concentrations of CSF markers in gene-expansion negative controls and premanifest and manifest gene-expansion carriers Concentrations of CSF.

Neuroglia Notes.

Neuroglial Cells.

Fig. 3. Occludin and ZO-1 decrease in hippocampus of aged SHRs. A

Figure 4 C5B3 decreased NMOSD mouse model lesions in vivo

Figure 3 The possible role of keratinocytes in CRPS pathophysiology

Presentation transcript:

Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.127 Figure 1 Candidate fluid biomarkers for pathophysiological processes related to traumatic brain injury Figure 1 | Candidate fluid biomarkers for pathophysiological processes related to traumatic brain injury. Tau and neurofilament light (NFL) and neurofilament heavy (NFH), as well as spectrin breakdown products (SBDPs), are biomarkers for axonal injury. Myelin basic protein (MBP) is a candidate biomarker for white matter integrity. Neuron-specific enolase (NSE) and ubiquitin C-terminal hydrolase-L1 (UCHL1) are proteins that show enrichment in the neuronal soma, and are putative biomarkers for neuronal injury. In traumatic brain injury, activated astrocytes and microglia secrete S100-B and glial fibrillary acidic protein (GFAP), as well as interleukins, cytokines and matrix metalloproteinases. The cerebrospinal fluid (CSF):serum albumin ratio is an established biomarker for blood–brain and/or blood–CSF barrier integrity. Plasma occludin is a candidate biomarker in the blood for the same function. Zetterberg, H. & Blennow, K. (2016) Fluid biomarkers for mild traumatic brain injury and related conditions Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.127