Anticoagulation monitoring during vascular surgery: accuracy of the Hemochron® low range activated clotting time (ACT-LR) B. Tremey, B. Szekely, S. Schlumberger,

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Anticoagulation monitoring during vascular surgery: accuracy of the Hemochron® low range activated clotting time (ACT-LR) B. Tremey, B. Szekely, S. Schlumberger, D. François, N. Liu, K. Sievert, M. Fischler British Journal of Anaesthesia Volume 97, Issue 4, Pages 453-459 (October 2006) DOI: 10.1093/bja/ael194 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 Relevance of clinical decisions based on ACT-LR values during vascular surgery; the error grid analysis graph was obtained with these assumptions. ACT-LR, activated clotting time low range. British Journal of Anaesthesia 2006 97, 453-459DOI: (10.1093/bja/ael194) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 Linear regression analysis between ACT-LR measurements and anti-Xa activity. Bold line = regression line. ACT-LR, activated clotting time low range. British Journal of Anaesthesia 2006 97, 453-459DOI: (10.1093/bja/ael194) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 ROC curves for ACT-LR in predicting three different anti-Xa activity: 0.6, 0.8, 1 u ml−1. For each threshold, optimal ACT-LR regarding Kappa values are represented. British Journal of Anaesthesia 2006 97, 453-459DOI: (10.1093/bja/ael194) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 4 Specific relationship between Hemochron® ACT-LR measurements and anti-Xa activity. Pearson's correlation and error grid analysis graph showing the categorization of ACT-LR in six zones describing the clinical implications of estimate errors. The median slope represents the linear regression slope. The upper divergent diagonal represents a 10% overestimation and the lower a 10% underestimation. Other zones are defined as described in Materials and methods. ACT-LR, activated clotting time low range. British Journal of Anaesthesia 2006 97, 453-459DOI: (10.1093/bja/ael194) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions