DSS + αIL10R colitis is associated with differential changes of bacterial composition in the lumen and mucosa. DSS + αIL10R colitis is associated with.

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DSS + αIL10R colitis is associated with differential changes of bacterial composition in the lumen and mucosa. DSS + αIL10R colitis is associated with differential changes of bacterial composition in the lumen and mucosa. (A to D) 16S rRNA sequencing of colonic lumen contents or MA preparations 2 weeks after initiation of IgG or DSS + αIL10R. n = 8. Data are mean bacterial changes at the phyla (A) or family (B) level, and principal coordinates analysis on unweighted UniFrac distances (C). (D) Bacteria enriched during colitis. OTUs enriched in DSS + αIL10R mice with average percentage of >1% and Benjamini-Hochberg–adjusted P value of <0.05 (Mann-Whitney U) from lumen contents or MA preparations. (E) Increase of H. typhlonius in the mucosa with colitis. Percentages of H. typhlonius and H. apodemus OTUs are shown (Benjamini-Hochberg–adjusted: P = 0.0009, P = 0.0023, P = 0.0277, Mann-Whitney U test; n = 8). (F) Marked expansion of Bacteroides species in the lumen with colitis. Percentages of B. vulgatus, B. acidifaciens, and B. uniformis OTUs are shown (Benjamini-Hochberg–adjusted: P = 0.0009, P = 0.0086, P = 0.0009, P = 0.0086, P = 0.0266, Mann-Whitney U test; n = 8). Bars indicate mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. Jiani N. Chai et al. Sci. Immunol. 2017;2:eaal5068 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works