Recombinant Inbred Strains: Step 1: Initial Mendelian Cross

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Presentation transcript:

Recombinant Inbred Strains: Step 1: Initial Mendelian Cross P1 P2 : Parental strains. Homozygous at all loci, but differing in phenotype. F1: First filial. Heterozygous at all loci. Breed with one another to get F2. F2: Second filial. Recombination in F1 gametes gives a mixture of P1 and P2 chromosome sections. Recombinant Inbred Strains: Step 1: Initial Mendelian Cross P1 P2

Recombinant Inbred Strains: Step 2: Sib-matings × F2 × F3 × FA Lot

Recombinant Inbred Strains: Phenomenon 1: Recombination will break up the red versus blue segments. Note how there is more red/blue combinations in F3 than in F2. × F2 × F3

Recombinant Inbred Strains: Phenomenon 2: Sib matings increase homozygosity. After a large number of generations (20 is close to “large”), one creates inbred strains that are identical at all loci. × F3 × FA Lot

Common Sense Explanation: Recombination breaks up the red versus blue areas. But within a line of sib matings, the SAME red/blue combinations are transmitted and, after a long time, become homozygous..

Recombinant Inbred Strains: At each locus, ½ of the strains should be rr and the other 1/2 will be bb. Do a t-test using phenotypic scores as the dependent variable and genotype ( rr versus bb) as the group variable. If the test is significant, then that gene (or more likely, a gene close to the genotyped locus) influences the phenotype. A more complicated approach would use haplotypes. Recombinant Inbred Strains: Linkage Analysis