Dr Mahmood S. Mozaffari, Stephen W. Schaffer Kidney International

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Chronic taurine treatment ameliorates reduction in saline-induced diuresis and natriuresis Dr Mahmood S. Mozaffari, Stephen W. Schaffer Kidney International Volume 61, Issue 5, Pages 1750-1759 (May 2002) DOI: 10.1046/j.1523-1755.2002.00317.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Effects of chronic taurine treatment on isotonic saline-stimulated diuresis and natriuresis by the unilaterally nephrectomized (UNX) control rat (ages 3 to 9 months). (A and B) Diuretic and natriuretic responses to a saline challenge, expressed as the percent of the administered fluid and sodium loads that are excreted within 90 minutes of the saline load. (C and D) Excretion data normalized relative to kidney weight. Symbols are: (▪) sham operated; () UNX; () UNX/taurine; *P < 0.05 compared to 3-month-old UNX group and their age-matched UNX-taurine counterparts; **P < 0.05 compared to 9-month-old sham-operated group; #P < 0.05 compared to their age-matched UNX counterpart. Kidney International 2002 61, 1750-1759DOI: (10.1046/j.1523-1755.2002.00317.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Effects of chronic taurine treatment on saline-stimulated diuresis and natriuresis by unilaterally nephrectomized (UNX) glucose intolerant rats. (A and B) Diuretic and natriuretic responses to a saline load, expressed as the percent of the administered fluid and sodium loads that are excreted within 90 minutes of the saline load. (C and D) Excretion data normalized relative to kidney weight. Symbols are: (▪) sham operated; () UNX; () UNX/taurine; *P < 0.05 compared to their age-matched sham or UNX-taurine counterparts; **P < 0.05 compared to 9-month-old UNX group; #P < 0.05 compared to the 3-month-old sham group. Kidney International 2002 61, 1750-1759DOI: (10.1046/j.1523-1755.2002.00317.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Glomerular filtration rate (GFR), fractional excretion of fluid and sodium by sham-operated (○), unilaterally nephrectomized (UNX; •) and taurine treated UNX (□) rats. (A–C) Six-month-old control rat data. (D–F) Six-month-old glucose intolerant rat data. *P < 0.05 compared to the UNX/taurine group at the same time point. Kidney International 2002 61, 1750-1759DOI: (10.1046/j.1523-1755.2002.00317.x) Copyright © 2002 International Society of Nephrology Terms and Conditions