SoftVue C25

Click to go back to previous slide Click to go to next slide Navigation Click to go to home page Click to go back to previous slide Click to go to next slide

Home Page Objectives Different Types of Breast Imaging Breast Tissue and Density What Doctors are Looking For Different Types of Breast Imaging SoftVue Conclusion References

Objectives Discuss breast tissue and density Density Categories Explain what doctors are looking for Calcifications and masses Describe different types of breast imaging MRI, Ultrasound, 2-D mammography, 3-D/tomosyntheisis Explore SoftVue Conclusion References

Breast Tissue and Density

Breast Tissue Breasts are made up of lobules, ducts, and fatty and fibrous connective tissue. Lobules produce milk and are often called glandular tissue. Ducts are the tiny tubes that carry milk from the lobules to the nipple. Fibrous tissue and fat give breasts their size and shape and hold the other tissues in place.1

Breast Tissue Your breasts are Breast density is seen only on mammograms. Some women think that because their breasts are firm, they are dense. Breast density isn’t based on how your breasts feel. It’s not related to breast size or firmness. 1 Your breasts are considered dense if you have a lot of fibrous or glandular tissue and not much fat in the breasts. Some women have more dense breast tissue than others. For most women, breasts become less dense with age. But in some women, there’s little change.

Breast density Breast density is based on how fibrous and glandular tissues are distributed in your breast, as opposed to how much of your breast is made up of fatty tissue. Dense breasts are not abnormal, but they are linked to a higher risk of breast cancer. Dense breast tissue can also make it harder to find cancers on a mammogram.1

Breast Density Categories Radiologists use the Breast Imaging Reporting and Data System, or BI-RADS, to classify breast density into 4 categories. They go from almost all fatty tissue to extremely dense tissue with very little fat. Women who have dense breast tissue seem to have a slightly higher risk of breast cancer compared to women with less dense breast tissue. It’s unclear at this time why dense breast tissue is linked to breast cancer risk.1

Breast Density Categories There are scattered areas of dense glandular and fibrous tissue. Breasts are almost all fatty tissue.

Breast Density Categories More of the breast is made of dense glandular and fibrous tissue (described as "heterogeneously dense"). This can make it hard to see small tumors in or around the dense tissue. Breasts are extremely dense, which makes it hard to see tumors in the tissue.1 

What Doctors are looking for

Microcalcifications Calcifications Macrocalcifications Tiny calcium deposits within the breast tissue. They look like small white spots and they may or may not be caused by cancer. There are 2 types of calcifications. Macrocalcifications Larger calcium deposits that are most likely due to changes caused by aging of the breast arteries, old injuries, or inflammation. These deposits are typically related to non-cancerous conditions and don’t need to be checked for cancer with a biopsy. Macrocalcifications become more common as women get older (especially after age 50). Microcalcifications Microcalcifications are tiny specks of calcium in the breast. When seen on a mammogram, they are more of a concern than macrocalcifications, but they don’t always mean that cancer is present. The shape and layout of microcalcifications help the radiologist judge how likely it is that the change is due to cancer.1

MICROCALCIFICATIONS MACROCALCIFICATIONS

Masses A mass is the same as a lump or a tumor; with or without calcifications CYSTS FIBROADENOMAS Fluid-filled masses in the breast. Very common and are rarely associated with cancer. A follow-up ultrasound is the best way to tell a cyst from a cancer Sound waves pass right through a liquid-filled cyst. Solid lumps, on the other hand, bounce the waves right back to the film. Movable, solid, rounded lumps made up of normal breast cells. While not cancerous, these lumps may grow. Any solid lump that's getting bigger is usually removed to make sure that it's not a cancer. Most common kind of breast mass, especially in young women.1

Different Types of Breast imaging

MRI Machine that uses magnets to create images of the breast Used in women who already have been diagnosed with breast cancer help measure the size of the cancer, look for other tumors in the breast, and check for tumors in the opposite breast. For certain women at high risk for breast cancer, a screening MRI is recommended along with a yearly mammogram MRI is not recommended as a screening test by itself because it can miss some cancers that a mammogram would find.2

Ultrasound Useful for looking at some breast changes, such as lumps (especially those that can be felt but not seen on a mammogram) or changes in women with dense breast tissue. Can look at a change that was seen on a mammogram. Tells the difference between fluid-filled cysts and solid masses Ultrasound is widely available, easy to have, and does not expose a person to radiation. It also costs less than a lot of other options.2

2-D Mammography Uses x-ray technology to produce a diagnostic image Basic screening tool for annual mammograms2

3-d/tomosyntheisis Advanced technology that allows you to make multiple images or x-rays of the breast tissue to create a 3d image Any woman who is in the category of having dense breasts should consider this type of mammogram Helps detect cancer quicker and also allows for doctors to see the cancer size much better Recalls not as common2

SoftVue

What is SoftVue? SoftVue uses ultrasound waves that are sent through a ring-like transducer that emits ultrasound signals in a sequenced 360 array, which surrounds the breast submerged in the water bath. It captures… Masses and the sound signal that goes through the tissue and capture it on the other side to see the change in the sound speed This now only allows us to see the mass but also the characteristics of the mass-is it cancer or a cyst? 3

Benefits of SoftVue Does not expose the patient to radiation, compression and no contact needed with the breasts besides to the water. Can take less that 2 minutes per breast, and will include the whole chest wall. The radiologist is not only able to identify masses, but the characteristics of the mass as well. Can potentially detect breast cancer that is masked by dense breast tissue, more accurately than ultrasound, and without the compression of a normal mammogram.4

Process of SoftVue The patient would be assisted to lie on their stomach on the table. Once on the table, one breast at a time will be emerged into the warm bath reservoir. A soft gel guide, which is the sequel breast interface, engages with the front of the breast to center it, shape it, and keep it still for the exam. The volumetric ring transducer then encircles the breast including the nipple to the chest wall, in 2mm increments Three distinct imaging volumes are produced showing attenuation, speed of sound, and reflection.5

She lowers one breast into the warm water of the imaging area Step One Step Four Patient approaches SoftVue to lie on her stomach on the comfort-padded tabletop Step Two The scan is activated, and the ring transducer moves along the breast, imaging all levels She lowers one breast into the warm water of the imaging area Step Five Step Three When the first scan is complete, the patient raises slightly to prepare for the next scan5 The Sequr breast interface engages with the front of her breast to center, shape, and steady it

SoftVue Currently SoftVue has received two 510(k) clearances from the FDA for diagnostic breast imaging It is only being used as of now, in research and in addition to a 2D or 3D mammogram screening, not as a replacement to a normal screening exam6

Conclusion Breast cancer sadly has taken the lives of many women and men, but being a breast cancer survivor is becoming much more common. Self examinations and yearly mammograms are so important in women and men’s health and can help prevent breast cancer from spreading before it's too late. Advancements in breast imaging such as tomosynthesis, have already improved recalls on mammograms and detected cancers quicker. Just imagine the same outcome but with no compression, radiation or contact in the future. SoftVue’s ring-like transducer sends out ultrasound signals which in return , allows radiologist to not only identify masses, but the characteristics of the mass. The future looks bright in the breast imaging world and if you want to keep seeing positive change, volunteer for the SoftVue product!

Image References -Slide 5 Anon, (2018). [image] Available at: https://www.vbcf.org/wp-content/uploads/2016/01/Breast-Cancer-Stats-US.png [Accessed 29 Mar. 2018]. -Slide 6 Anon, (2018). [image] Available at: http://mammalive.net/resources/decrease-breast-density-reduce-breast-cancer- risk [Accessed 29 Mar. 2018]. -Slide 7, 8, 10, 24 Anon, (2018). [image] Available at: https://www.bing.com/images/search?view=detailV2&ccid=55%2bP%2fPHO&id=4904B4086DC5DF5E3BD08CFC D213D191C6BD435C&thid=OIP.55-P_PHOZ- _ed9w_X778LgHaJx&mediaurl=http%3a%2f%2fwavenewspapers.com%2fwp- content%2fuploads%2f2016%2f10%2fbreastcancer.jpg&exph=924&expw=700&q=breast+cancer+statistics&simid =608029112011917570&selectedIndex=4&ajaxhist=0 [Accessed 29 Mar. 2018]. -Slide 15 2018). [image] Available at: http://www.ladycarehealth.com/wp-content/uploads/2012/08/microcalcifications.jpg [Accessed 29 Mar. 2018]. Anon, (2018). [image] Available at: https://www.bing.com/images/search?view=detailV2&ccid=LpgVchnO&id=63D6AC43173C1B597F9E43A2585590 1E2EF54095&thid=OIP.LpgVchnOfdLc95o30dQiGAHaKf&mediaurl=http%3a%2f%2fimages.radiopaedia.org%2fi mages%2f4040883%2f684c07109e5ad227d35646d6753640_gallery.JPG&exph=442&expw=312&q=macrocalcificat ions+in+breast&simid=608048778718412949&selectedIndex=14&ajaxhist=0 slide 15 [Accessed 29 Mar. 2018].

Image References Continued… -Slide 17 Anon, (2018). [image] Available at: http://www.bostonbdc.com/images/AuroraMRI-080430_222-LoRes.jpg [Accessed 30 Mar. 2018]. Anon, (2018). [image] Available at: http://www3.gehealthcare.com/en/Products/Categories/~/media/Images/Product/Product- Categories/Ultrasound/LOGIQ/LOGIQ-E9/Logiq_E9_Clinical_setting_patient.jpg?h=225&w=400 [Accessed 30 Mar. 2018]. Anon, (2018). [image] Available at: https://www.bing.com/images/search?view=detailV2&ccid=nxekwjlR&id=66AD4A712807721DAE02E5D8981ED 879C861898C&thid=OIP.nxekwjlR_78_sy0c4nKubwHaEx&mediaurl=http%3a%2f%2fwww.windsongradiology.c om%2fwp-content%2fuploads%2f2011%2f12%2f3d-digital- mammography.jpg&exph=1260&expw=1956&q=3d+tomosynthesis+on+patient&simid=608022313120629142&s electedIndex=15&ajaxhist=0 [Accessed 30 Mar. 2018]. -Slide18 2018. Available at: https://www.bing.com/images/search?view=detailV2&ccid=4dCHwBP9&id=1044F4714BDF3178AAE9241AFF37 73946872B6DC&thid=OIP.4dCHwBP9jghbPOBAPbU5OgHaGb&mediaurl=http%3a%2f%2fwww.caperay.com% 2fblog%2fwp- content%2fuploads%2f2012%2f07%2fMRI_Destounis&exph=989&expw=1139&q=mammography+mri+images& simid=607999489641483935&selectedIndex=11&ajaxhist=0. Accessed March 30, 2018. -Slide 19 18. ; 2018. Available at: https://www.bing.com/images/search?view=detailV2&ccid=%2fprEfa4U&id=7DF2C1AD4651E2FF39FC8409F90 087EE1A11E497&thid=OIP._prEfa4Udqb0hJGITEZRMAHaFA&mediaurl=http%3a%2f%2fwww.mayoclinic.org %2f-%2fmedia%2fkcms%2fgbs%2fpatient- consumer%2fimages%2f2013%2f08%2f26%2f10%2f54%2fmy00308_im03608_pr7_breastcystthu_jpg.ashx&exph= 316&expw=468&q=mammorgraphy+ultrasound++imags&simid=607987322041535630&selectedIndex=44&ajax hist=0. Accessed March 30, 2018.

Image References Continued... -Slide 20 Anon, (2018). [image] Available at: https://www.bing.com/images/search?view=detailV2&ccid=IBqIJUv3&id=7C034D0C3A4326EDEAC6E0B2F6A1 BB53ED6072BA&thid=OIP.IBqIJUv3q_4wPNcN7Z3PDwHaFj&mediaurl=http%3a%2f%2fwww.wdio.com%2fwd ioimages%2frepository%2f2017- 06%2fimg1142.jpg&exph=600&expw=800&q=2D+Mammogram+Machine&simid=608042589649111080&selecte dIndex=0&ajaxhist=0 [Accessed 29 Mar. 2018]. -Slide 21 2018. Available at: https://www.bing.com/images/search?view=detailV2&ccid=9FyYmCwe&id=4E779B1EBAAD1B2CAAED52CC90 9C9C3373E0F898&thid=OIP.9FyYmCweMZHWPYcMihKr- gHaDy&mediaurl=http%3a%2f%2foceanradiology.com%2fimages%2ftomo.jpg&exph=410&expw=800&q=3d+tom o+image&simid=607992579013020269&selectedIndex=17&ajaxhist=0.[Accessed March 30, 2018]. -Slide 23 Anon, (2018). [image] Available at: https://www.medgadget.com/2014/01/delphinus-medicals-softvue-ultrasound- tomography-system-cleared-in-u-s.html [Accessed 29 Mar. 2018]

Citations >Citation 1 Cancer.org. (2017). What Does the Doctor Look for on a Mammogram?. [online] Available at: https://www.cancer.org/cancer/breast-cancer/screening-tests-and-early- detection/mammograms/what-does-the-doctor-look-for-on-a-mammogram.html [Accessed 29 Mar. 2018]. >Citation 2 Mayo Clinic. (2018). Dense breast tissue may increase the risk of breast cancer. [online] Available at:https://www.mayoclinic.org/tests-procedures/mammogram/in-depth/dense- breast-tissue/art-20123968?pg=2 [Accessed 15 March. 2018]. >Citation 3 New Technology leads to Comfortable Mammography alternativeIn-text: (Bouffard, 2015) Bouffard, K. (2015).New Technology leads to Comfortable Mammography alternative. Detroit News [Accessed 15 March. 2018] >Citation 4 Bramlet, K. (2015). What you should know about 3-D mammography. [online] MD Anderson Cancer Center. Available at: https://www.mdanderson.org/publications/focused-on-health/october-2015/FOH-3D- mammography.html [Accessed 15 March. 2018].

Citations Continued… >Citation 5 Delphinus Medical Technologies. (2018). SoftvueTM System - Delphinus Medical Technologies. [online] Available at:http://www.delphinusmt.com/technology/ [Accessed 15 March. 2018]. >Citation 6 Dacha, M. (2018). An Innovative Whole-Breast Ultrasound Technology Could Be Life- Saving | Keck Medicine of USC. [online] Keckmedicine.org. Available at: https://www.keckmedicine.org/whole-breast-ultrasound/ [Accessed 18 March. 2018].