SNARE motif sequence alignment of GOSR2 and its yeast ortholog, Bos1.

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Presentation transcript:

SNARE motif sequence alignment of GOSR2 and its yeast ortholog, Bos1. SNARE motif sequence alignment of GOSR2 and its yeast ortholog, Bos1. The PME-associated mutations of GOSR2, p.Gly144 and p.Lys164, as well as the yeast ortholog Bos1 p.Gly176 and p.Arg196, are located at highly conserved positions within the SNARE motif. GOSR2 and Bos1 contain an N-terminal Habc domain, a SNARE motif and a transmembrane domain (TM) at the C-terminus. Sequence alignments of SNARE proteins of over 200 animals or fungi are presented as weblogo and show the high sequence conservation of the SNARE domain (Crooks et al., 2004). GOSR2 and Bos1 share high sequence similarity. The SNARE motif consists of 16 hydrophobic layers, as indicated. The p.Gly144 and p.Gly176 mutations are located at the −3 layer, whereas p.Lys164 and p.Arg196 are located between layers +2 and +3 (Kloepper et al., 2007). Jörn M. Völker et al. Dis. Model. Mech. 2017;10:1391-1398 © 2017. Published by The Company of Biologists Ltd