Fig. 2. Chd1l is a candidate developmental regulator

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Fig. 2. Chd1l is a candidate developmental regulator Fig. 2. Chd1l is a candidate developmental regulator.(A) Chd1l mRNA expression. Chd1l is a candidate developmental regulator.(A) Chd1l mRNA expression. Chd1l mRNA is enriched in the ICM (yellow) compared to the whole blastocyst (green). (B) Chd1l protein structure. Chd1l is a SNF2 chromatin remodeling enzyme containing a split ATPase/helicase and a macro domain. (C) Chd1l expression during preimplantation development (Wang et al., 2004). Chd1l expression peaks at the late morula stage before it becomes compartmentalized in the inner cell mass of the blastocyst. (D) Decision tree for choosing Chd1l. Chd1l was chosen as a candidate developmental regulator because of its compartmentalization in the ICM and peak expression at the late morula state and its predicted role as a regulator of chromatin. Alyssa C. Snider et al. Biology Open 2012;bio.20122949 © 2012. Published by The Company of Biologists Ltd