Complement activation by synthetic vascular prostheses

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Presentation transcript:

Complement activation by synthetic vascular prostheses Alexander D. Shepard, M.D., Jeffrey A. Gelfand, M.D., Allan D. Callow, M.D., Ph.D., Thomas F. O'Donnell, M.D. Journal of Vascular Surgery Volume 1, Issue 6, Pages 829-838 (November 1984) DOI: 10.1016/0741-5214(84)90015-6 Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 A, Scanning electron micrograph of surface of knitted Dacron graft after 2.5 hours of flow in ex vivo shunt circuit. Note large number of adherent PMNs (arrows). (Original magnification ×3200.) B, Higher magnification showing adherent PMN. Membrane ruffling and pseudopod formation indicate activated state. (Original magnification ×13,500.) Journal of Vascular Surgery 1984 1, 829-838DOI: (10.1016/0741-5214(84)90015-6) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Scanning electron micrograph of surface of PTFE graft after 2.5 hours of flow in exvivo shunt circuit. Platelets, protein, and red blood cells adhere to surface. Note absence of white cells. (Original magnification ×3500.) Journal of Vascular Surgery 1984 1, 829-838DOI: (10.1016/0741-5214(84)90015-6) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 The complement system. Journal of Vascular Surgery 1984 1, 829-838DOI: (10.1016/0741-5214(84)90015-6) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Mean ± SEM C5a levels (by radioimmunoassay) generated in plasma samples from 10 healthy donors by incubation with segments of knitted Dacron PTFE graft material. Journal of Vascular Surgery 1984 1, 829-838DOI: (10.1016/0741-5214(84)90015-6) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Granulocyte aggregometry tracings showing greater PMN aggregation (as measured by large increase in light transmission [ΔT]) for plasma exposed to knitted Dacron than to PTFE. Zymosan-activated plasma (ZAP) (4 mg zymosan/1 ml plasma) reflects maximal PMN aggregation by known potent activator of complement system. Journal of Vascular Surgery 1984 1, 829-838DOI: (10.1016/0741-5214(84)90015-6) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Mean ± SEM depletion of functional complement activity in plasma incubated with knitted Dacron and PTFE, as determined by standard hemolytic assays. One hundred percent represents activity present in control plasma unexposed to either graft material. The p values obtained from two-tailed Student's t test are p < 0.001 for CH50, p < 0.05 for C4, and p < 0.001 for APH50. Journal of Vascular Surgery 1984 1, 829-838DOI: (10.1016/0741-5214(84)90015-6) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions