Figure 2 Assessment of systemic disease activityTc99 scintigraphy (A) and fluorodeoxyglucose PET imaging (B, C) at disease onset 2 years before acute deterioration.

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Figure 2 Assessment of systemic disease activityTc99 scintigraphy (A) and fluorodeoxyglucose PET imaging (B, C) at disease onset 2 years before acute deterioration (A), at current presentation (B), and at 6-month follow-up (C) show regression of glucose uptake in bone lesions under vemurafenib treatment (B, C). Assessment of systemic disease activityTc99 scintigraphy (A) and fluorodeoxyglucose PET imaging (B, C) at disease onset 2 years before acute deterioration (A), at current presentation (B), and at 6-month follow-up (C) show regression of glucose uptake in bone lesions under vemurafenib treatment (B, C). PET images were normalized to standardized uptake values. (D) C-reactive protein levels (mg/L) decreased upon targeted therapy. The course of disease is shown from first presentation to the Department of Dermatology to 6-month follow-up. Philipp Euskirchen et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e78 © 2015 American Academy of Neurology