Varying Mutational Alterations in Multiple Primary Melanomas

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Varying Mutational Alterations in Multiple Primary Melanomas Friederike Egberts, Ann-Sophie Bohne, Sandra Krüger, Jürgen Hedderich, Rainer Rompel, Jochen Haag, Christoph Röcken, Axel Hauschild The Journal of Molecular Diagnostics Volume 18, Issue 1, Pages 75-83 (January 2016) DOI: 10.1016/j.jmoldx.2015.07.010 Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 A: Distribution pattern of mutational alterations of BRAF, NRAS, and TERT promoter in all melanoma samples (n = 228). B: Distribution of BRAF, NRAS, and TERT-promoter mutations in patients with mutation patterns consistent between first and subsequent melanomas (n = 29). The Journal of Molecular Diagnostics 2016 18, 75-83DOI: (10.1016/j.jmoldx.2015.07.010) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 Distant metastasis–free survival, by NRAS-mutation status (NRAS mutation versus NRAS wild type). The Journal of Molecular Diagnostics 2016 18, 75-83DOI: (10.1016/j.jmoldx.2015.07.010) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions