KGF enhances AECII proliferation and susceptibility to IAV infection.

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KGF enhances AECII proliferation and susceptibility to IAV infection. KGF enhances AECII proliferation and susceptibility to IAV infection. Mice were treated with i.t. KGF (5 mg/kg) 0, 24, 48, or 120 h before IAV infection. Twenty-four hours after challenge with IAV, lungs were harvested and dissociated and dispersed-lung cells were stained with antibody to pro SP-C, IAV-NP, and Ki67 and analyzed by flow cytometry. (A) Experimental timeline for B–D is shown. (B) Percentage of pro SP-C–positive cells that also expressed the proliferation marker Ki67 was determined. (C) Percentage of pro SP-C–positive cells that were infected with IAV was determined by measuring IAV-NP staining. (D) Mean channel fluorescence (MCF) of IAV-NP staining in pro SP-C–positive cells are shown (n = 4/group). **P < 0.01; ***P < 0.001. Nikolaos M. Nikolaidis et al. PNAS 2017;114:32:E6613-E6622 ©2017 by National Academy of Sciences