Azithromycin treatment eliminates NTHi infection.

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Azithromycin treatment eliminates NTHi infection. Azithromycin treatment eliminates NTHi infection. (A,C) Time course of ME infection rate (A) and titre (C) for 8-week-old Jbo/+ mice inoculated with 106 CFU of NTHi 162 (n=11-12 per time point). (B,D) Jbo/+ mice were treated with 100 mg/kg azithromycin (AZM) by oral gavage once a day for 3 days starting on day 4 post-inoculation with 106 CFU of NTHi 162, and sampled at day 7. (B) ME infection rate was significantly reduced in the AZM-treated group. (D) NTHi titre in the vehicle-treated group was 105.3 CFU/µl (105.1-105.4), whereas NTHi were not detected in the AZM-treated group (detection limit 102 CFU/µl); n=15 Jbo/+ per group. Data are represented as mean±95% CI. (B) Fisher’s exact test. (D) One-sample t-test using a hypothetical sample mean of 102 CFU/µl. ***P<0.001. Derek Hood et al. Dis. Model. Mech. 2016;9:69-79 © 2016. Published by The Company of Biologists Ltd