KGF enhances AECII proliferation and susceptibility to IAV infection, ex vivo. KGF enhances AECII proliferation and susceptibility to IAV infection, ex.

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KGF enhances AECII proliferation and susceptibility to IAV infection, ex vivo. KGF enhances AECII proliferation and susceptibility to IAV infection, ex vivo. AECII were isolated from mice that were treated with i.t. KGF (5 mg/kg) 24, 48, or 120 h before AECII isolation, incubated with IAV in media or media alone ex vivo for 18 h, fixed and stained with antibodies to Ki67, pro SP-C, and IAV-NP, and analyzed by flow cytometry. (A) Experimental timeline for B–D is shown. (B) Percentage of pro SP-C–positive cells that also expressed Ki67 was determined. (C) Percentage of pro SP-C–positive cells that stained with IAV-NP are shown. (D) MCF of IAV-NP in pro SP-C–positive cells is shown. (E) Two-parameter histogram of Ki67 vs. IAV-NP staining of AECII isolated from mice pretreated with KGF 48 h before isolation and infected ex vivo is shown. Cells were harvested and analyzed by flow cytometry at 24 h after infection. Representative IAV-NP staining of Ki67-positive AECII (upper histogram) and Ki67-negative AECII (lower histogram) is shown. IAV-NP mean channel MCF data are shown for one of two independent experiments (n = 4). (F) Western blot of AECII isolated from mice that were treated with i.t. KGF (5 mg/kg) 24, 48, 120 h before AECII isolation and incubated with IAV in media or media alone ex vivo for 18 h before harvesting. Blots were stained with antibodies to IAV M1 and to GAPDH as a loading control. (G) Densitometry analysis of AECII Western blot is shown. *P < 0.05; ***P < 0.001. Nikolaos M. Nikolaidis et al. PNAS 2017;114:32:E6613-E6622 ©2017 by National Academy of Sciences