Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat J.L. Martin, D. Ma, M. Hossain, J. Xu,

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Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat J.L. Martin, D. Ma, M. Hossain, J. Xu, R.D. Sanders, N.P. Franks, M. Maze British Journal of Anaesthesia Volume 98, Issue 2, Pages 236-240 (February 2007) DOI: 10.1093/bja/ael340 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Experimental protocol for the different treatment strategies. British Journal of Anaesthesia 2007 98, 236-240DOI: (10.1093/bja/ael340) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) Schematic of rat pup’s brain and the location of representative sections harvested. (b) Representative brain sections stained with cresyl violet from a rat pup exposed to HI insult for 90 min. (c) Representative brain sections stained with cresyl violet from a rat pup exposed to 90 min of HI followed by asynchronous administration of xenon and hypothermia at a 1 h interval. British Journal of Anaesthesia 2007 98, 236-240DOI: (10.1093/bja/ael340) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 3 Graphs showing infarct size at different distances from the Bregma in rat pups exposed to hypothermia or xenon: (a) 20% xenon administered 6 h after HI; (b) hypothermia (35°C) 1 h after HI. Asynchronous administration of hypothermia (35°C) and xenon (20%) 1 (c) and 5 (d) h apart. British Journal of Anaesthesia 2007 98, 236-240DOI: (10.1093/bja/ael340) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 4 Comparison of the AUC for infarct volume against different interventions; hypothermia, xenon, and asynchronous administration of xenon and hypothermia at 1 and 5 h apart. British Journal of Anaesthesia 2007 98, 236-240DOI: (10.1093/bja/ael340) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions