Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Representative illustrations.

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Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Control (A,C) and CS-exposed (B,D) mice. Notice the alveolar destruction after CS exposure in B (arrow). Presence of foamy macrophages and lymphocytes were observed around the airways (arrow in D) after 6 months of CS exposure. Airspace enlargement was quantified by measuring mean linear intercept (Lm). Notice that Lm was significantly increased in the CS-exposed animals but only after 6 months of exposure (E). In E, each square represents data of an individual mouse; horizontal line represents mean and vertical lines the standard deviation. **P<0.01. Manuela Rinaldi et al. Dis. Model. Mech. 2012;5:333-341 © 2012. Published by The Company of Biologists Ltd