Objective response rate in patients with BRCA-mutated HER2-negative breast cancer treated with PARPi versus those treated with monochemotherapy (controls). Objective response rate in patients with BRCA-mutated HER2-negative breast cancer treated with PARPi versus those treated with monochemotherapy (controls). The size of the squares is proportional to the weight of each study. PARPi, PARP inhibitor. Francesca Poggio et al. ESMO Open 2018;3:e000361 Copyright © European Society for Medical Oncology. All rights reserved.