Volume 121, Issue 3, Pages 526-535 (September 2001) Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia  Jan Tack, Philip Caenepeel, Benjamin Fischler, Hubert Piessevaux, Jozef Janssens  Gastroenterology  Volume 121, Issue 3, Pages 526-535 (September 2001) DOI: 10.1053/gast.2001.27180 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Pressure-volume relationship obtained by gradually increasing isobaric gastric distentions in 80 healthy controls and 160 patients with functional dyspepsia. Linear model fitting revealed no significant differences between both groups. Gastroenterology 2001 121, 526-535DOI: (10.1053/gast.2001.27180) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Pressure-perception relationship obtained by gradually increasing isobaric gastric distentions in 80 healthy controls and 160 patients with functional dyspepsia. Linear model fitting revealed a shift towards higher perceptions for the same distending pressures in patients. Gastroenterology 2001 121, 526-535DOI: (10.1053/gast.2001.27180) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Number of healthy subjects or functional dyspepsia patients that reported discomfort at a given distending pressure, expressed as the increase of the intra-balloon pressure over intra-abdominal pressure needed to induce discomfort or pain. The shaded area indicates the normal range (mean ± 2 SD). Hypersensitivity to gastric distention is present in 34% of the patients. A small subset of patients (9%) with thresholds above the mean + 2 SD of the control group are less sensitive to gastric distention. Gastroenterology 2001 121, 526-535DOI: (10.1053/gast.2001.27180) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 Mean intragastric volume at 5-minute intervals as measured by a gastric barostat in healthy volunteers, in dyspeptic patients with normal sensitivity to gastric distention, and in dyspeptic patients with hypersensitivity to gastric distention, before and after administration of a mixed liquid meal (time = 0). Ingestion of the meal induces a rapid and sustained increase in intragastric volume, reflecting a relaxation of the gastric fundus. The relaxation is significantly larger in controls than in dyspeptic patients, regardless of their sensitivity to gastric distention. Gastroenterology 2001 121, 526-535DOI: (10.1053/gast.2001.27180) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 5 Dyspepsia symptoms in 160 patients with functional dyspepsia. The figure depicts the number of patients grading individual symptoms as relevant or severe (score ≥ 2) in the subgroups with normal sensitivity or hypersensitivity to gastric distention. Postprandial pain, belching, and weight loss exceeding 5% of the initial body weight were significantly more prevalent in patients with hypersensitivity to gastric distention. Gastroenterology 2001 121, 526-535DOI: (10.1053/gast.2001.27180) Copyright © 2001 American Gastroenterological Association Terms and Conditions