Lanthanum pharmacokinetics: Are rat data misleading?

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Lanthanum pharmacokinetics: Are rat data misleading? Patrick C. D'Haese, Geert J. Behets, Marc E. De Broe, Stephen J.P. Damment Kidney International Volume 68, Issue 6, Pages 2907-2908 (December 2005) DOI: 10.1111/j.1523-1755.2005.00583_3.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Mean plasma lanthanum concentration profiles in healthy volunteers and dialysis patients after a single oral dose of lanthanum carbonate (Fosrenol; 4 × 250-mg chewable tablets) in Phase I clinical studies. Study LAM-IV-110: Phase I, open-label, randomized, 2-way crossover study comparing lanthanum carbonate administered during, and after food in healthy subjects. Study LAM-IV-111: Phase I, open-label, single- and multiple-dose study comparing lanthanum pharmacokinetics in dialysis patients and healthy subjects. Study SPD405-117: single-dose, open-label, parallel group study to assess lanthanum pharmacokinetics after oral and intravenous dosing in healthy male subjects. Poster presentation at ASN 2003 [5], full publications in preparation. Kidney International 2005 68, 2907-2908DOI: (10.1111/j.1523-1755.2005.00583_3.x) Copyright © 2005 International Society of Nephrology Terms and Conditions