Fig. 3 Conserved genomic association of PRC1 activity in different leukemic cells. Conserved genomic association of PRC1 activity in different leukemic.

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Fig. 3 Conserved genomic association of PRC1 activity in different leukemic cells. Conserved genomic association of PRC1 activity in different leukemic cells. (A) Cumulative H2AK119Ub ChIP-seq signals among all enriched loci in the R26CreERT2Cdkn2a−/−Ring1a−/−Ring1bf/f nontreated Lin− cells expressing the indicated oncogenic proteins show that H2AK119Ub accumulated to the same genomic loci upon transformation with different oncogenes. Rows are sorted by decreasing normalized intensity centered in the ±40-kb window surrounding the H2AK119Ub peaks. (B) Composite volcano plot showing the significantly differentially regulated genes 72 hours after 4-OHT or EtOH (treatment control) treatment in the R26CreERT2Cdkn2a−/−Ring1a−/−Ring1bf/f Lin− cells expressing the indicated oncogenic proteins. WT, wild type. (C) Percentage of H2AK119Ub-enriched promoters undergoing transcriptional activation (fold change ≥ 4) after loss of PRC1 activity. Expression was determined by RNA-seq analysis in the R26CreERT2Cdkn2a−/−Ring1a−/−Ring1bf/f Lin− cells expressing the indicated oncogenic proteins at 72 hours after the 4-OHT treatment. EtOH was used as control treatment. Red bars represent the percentage of H2AK119Ub-positive promoters (PRC1 direct targets); yellow bars represent the H2AK119Ub-negative promoters (PRC1 indirect targets). TSS, transcription start site. (D) P values of the significantly enriched pathways identified by gene ontology interrogation for the activated genes presented in (C). Left panels represent the functional pathways enriched among the PRC1 direct targets; right panels represent the functional pathways enriched among the PRC1 indirect targets. Alessandra Rossi et al. Sci Adv 2016;2:e1600972 Copyright © 2016, The Authors