Providing Constant Analgesia with OROS® Hydromorphone

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Providing Constant Analgesia with OROS® Hydromorphone Suneel Gupta, PhD, Gayatri Sathyan, PhD Journal of Pain and Symptom Management Volume 33, Issue 2, Pages S19-S24 (February 2007) DOI: 10.1016/j.jpainsymman.2006.09.009 Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Fluctuating plasma concentrations associated with IR and biphasic controlled-release formulations of pain medications can result in breakthrough pain. Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Cross-section of the OROS® patented Push-Pull™ pump. Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Release rate of hydromorphone from OROS® hydromorphone is consistent across dose strengths. Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Mean plasma hydromorphone concentration vs. time on log scale. Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 5 Plasma concentration vs. time profiles of IR hydromorphone and OROS® hydromorphone after single-dose administration.4 Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 6 Steady-state plasma concentration vs. time profiles of IR hydromorphone and OROS® hydromorphone.4 Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 7 The pharmacokinetics of OROS® hydromorphone are minimally affected by food.13 Journal of Pain and Symptom Management 2007 33, S19-S24DOI: (10.1016/j.jpainsymman.2006.09.009) Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions