Polyploidy Experimental Hematology Jeffrey Zimmet, Katya Ravid  Experimental Hematology  Volume 28, Issue 1, Pages 3-16 (January 2000) DOI: 10.1016/S0301-472X(99)00124-1

Figure 1 Polyploidy is achieved through a variety of cell cycles. Megakaryocytic endomitosis-A involves progression through the early stages of mitosis during the brief gap separating successive rounds of DNA replication. In contrast, endoreduplication, as occurs in the drosophila embryo, entails alternating synthesis and gap phases without evidence of mitotic entry. The process of acytokinetic mitosis, as occurs in hepatocytes, leads to the formation of binucleate cells through the skipping of cytokinesis Experimental Hematology 2000 28, 3-16DOI: (10.1016/S0301-472X(99)00124-1)

Figure 2 Stages of mitosis during a mitotic cell cycle (adapted from [155]). Anaphase A, which involves movement of sister chromatids into the multiple centrosomes (indicated in the figure by black dotes), is documented in megakaryocytes undergoing endomitosis [86,87]. According to Nagata et al. [86], in megakaryocytes undergoing polyploidization, anaphase B, which involves outward movement of the spindle poles and full chromatide separation, is missing as well as cytokinesis. The spindle checkpoint and the regulation of chromosome condensation occur during the transition from interphase to prophase Experimental Hematology 2000 28, 3-16DOI: (10.1016/S0301-472X(99)00124-1)