Adherence with topical treatment is poor compared with adherence with oral agents: Implications for effective clinical use of topical agents Jennifer.

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Presentation transcript:

Adherence with topical treatment is poor compared with adherence with oral agents: Implications for effective clinical use of topical agents Jennifer Krejci-Manwaring, MD, Martha Ann McCarty, MS, PA-C, Fabian Camacho, MS, MA, Christie L. Carroll, MD, Katherine Johnson, BA, CRC, Janeen Manuel, PhD, Rajesh Balkrishnan, PhD, Jennifer Hartle, MPH, Alan Fleischer, MD, Steven R. Feldman, MD, PhD Journal of the American Academy of Dermatology Volume 54, Issue 5, Pages S235-S236 (May 2006) DOI: 10.1016/j.jaad.2005.10.060 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Comparing adherence rates for prednisone and topicals. Over 3 weeks, adherence rates for prednisone and topicals by patient log were consistently greater than 95%. By electronic caps, adherence to prednisone declines very little over time. For topicals, adherence declined considerably in terms of doses taken and days taken correctly. Correct number of doses can be higher than number of days taken correctly if bottle is opened more than once on given day or if drug is taken after prescribed treatment interval. Journal of the American Academy of Dermatology 2006 54, S235-S236DOI: (10.1016/j.jaad.2005.10.060) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Adherence rates over 12 weeks for topical therapy: tacrolimus versus vehicle. Adherence rates for topical therapy by patient log are consistently greater than 90%. By electronic caps, overall adherence rates for correct number of doses and days taken correctly were much lower but were similar for topical tacrolimus and vehicle. In addition adherence rates decline at similar rate for both groups. Journal of the American Academy of Dermatology 2006 54, S235-S236DOI: (10.1016/j.jaad.2005.10.060) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions