Hypereosinophilic syndrome: A multicenter, retrospective analysis of clinical characteristics and response to therapy  Princess U. Ogbogu, MD, Bruce S. Bochner, MD, Joseph H. Butterfield, MD, Gerald J. Gleich, MD, Johannes Huss-Marp, MD, Jean Emmanuel Kahn, MD, Kristin M. Leiferman, MD, Thomas B. Nutman, MD, Florian Pfab, MD, Johannes Ring, MD, Marc E. Rothenberg, MD, PhD, Florence Roufosse, MD, Marie-Helene Sajous, MD, Javed Sheikh, MD, Dagmar Simon, MD, Hans-Uwe Simon, MD, PhD, Miguel L. Stein, MD, Andrew Wardlaw, MD, Peter F. Weller, MD, Amy D. Klion, MD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 6, Pages 1319-1325.e3 (December 2009) DOI: 10.1016/j.jaci.2009.09.022 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Clinical manifestations of HES. The clinical manifestations at initial presentation (A) and at the time of the retrospective analysis (B) are shown as the percentage of patients with evidence of organ involvement referable to a given category. Reported manifestations in each of the categories are listed in this article's Table E1 in the Online Repository at www.jacionline.org. Journal of Allergy and Clinical Immunology 2009 124, 1319-1325.e3DOI: (10.1016/j.jaci.2009.09.022) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Response to treatment. The bars represent response rates after 1 month of therapy (A) and reasons for drug discontinuation (B). Responses were defined as complete (normalization of absolute eosinophil count [AEC] and clinical symptom improvement), partial (reduction of AEC, but not to normal levels, and/or improvement in symptoms), or no response (neither reduction of AEC nor improvement in symptoms). Journal of Allergy and Clinical Immunology 2009 124, 1319-1325.e3DOI: (10.1016/j.jaci.2009.09.022) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Association of serum TARC but not serum IgE levels with prednisone responsiveness. Serum IgE (A) and TARC (B) levels for prednisone responders (n = 129 and 75, respectively) and nonresponders (n = 13 and 8, respectively) are shown by using box-and-whisker plots. The whiskers represent the minimum and maximum values and the horizontal lines represent the lower quartile, median, and upper quartile. Journal of Allergy and Clinical Immunology 2009 124, 1319-1325.e3DOI: (10.1016/j.jaci.2009.09.022) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions