EGFR Mutations in Squamous Cell Lung Cancer in Never-Smokers

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EGFR Mutations in Squamous Cell Lung Cancer in Never-Smokers Christina S. Baik, MD, MPH, Colin C. Pritchard, MD, PhD, Keith D. Eaton, MD, PhD, Laura Q. Chow, MD Journal of Thoracic Oncology Volume 8, Issue 1, Pages e6-e7 (January 2013) DOI: 10.1097/JTO.0b013e3182762d49 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Representative hematoxylin and eosin stained sections of SCC and ADC tumors from each case. A, Case 1: epidural mass (SCC), (B) case 1: pericardial fluid (ADC), (C) case 2: supraclavicular mass (SCC), and (D) case 2: pleural fluid (ADC). SCC, squamous cell carcinoma; ADC, adenocarcinoma. Journal of Thoracic Oncology 2013 8, e6-e7DOI: (10.1097/JTO.0b013e3182762d49) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Molecular testing results. A, An EGFR L858R mutation was identified in the SCC in patient 1 by melting curve analysis with a mutation-specific probe (black trace, small peak at ~63°C). B, A 15-base pair EGFR exon 19 deletion was identified in the SCC of patient 2 by capillary electrophoresis (peaks at ~102 base pair). Adenocarcinoma lesions from each patient shared the same EGFR mutation as the SCC component (data not shown). SCC, squamous cell carcinoma. Journal of Thoracic Oncology 2013 8, e6-e7DOI: (10.1097/JTO.0b013e3182762d49) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions