Impact of age on both BIS values and EEG bispectrum during anaesthesia with sevoflurane in children E Wodey, O Tirel, J.Y. Bansard, A Terrier, C Chanavaz,

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Presentation transcript:

Impact of age on both BIS values and EEG bispectrum during anaesthesia with sevoflurane in children E Wodey, O Tirel, J.Y. Bansard, A Terrier, C Chanavaz, R Harris, C Ecoffey, L Senhadji British Journal of Anaesthesia Volume 94, Issue 6, Pages 810-820 (June 2005) DOI: 10.1093/bja/aei140 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 1 An example of the representation of the 36 frequencies of coupling (Pi) of the bispectrum calculated every 20 s for one child's EEG (MatBis). British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) Expired sevoflurane concentration in the sub-group of 29 children during recording. (b) BIS index recorded during the decrease of sevoflurane concentration in the sub-group of 29 children. T0: at 2 MAC (4 min after intubation); T10: at the steady state at 1 MAC; T20: at the steady state at 0.5 MAC. Box plot (range; 10–90th centile; 25–75th centile; median). *vs T0: P<0.05; †vs T10 (1 MAC): P<0.05. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 3 (a) Structured model of the MCA obtained with the pattern of each individual EEG bispectrum, also showing the groups of children obtained through the hierarchical ascending classification. (b) Representation of the 36 frequencies of coupling (Pi) of the MatBis used to establish the structured model of the MCA. Arrows represent the contribution of the main Pi to the position of each child in the structured model of MCA. The units of axes F1 and F2 are arbitrary'representing distance between children as a function of the similarity or difference in their EEG bispectra at 1 MAC. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 4 Projection of age, weight, and BIS index values (recorded at the steady state at 1 MAC sevoflurane) onto the two dominant axes (F1 and F2) of the structured model of the MCA. The units of axes F1 and F2 are arbitrary'representing distance between children as a function of the similarity or difference in their EEG bispectra at 1 MAC. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 5 Change in position in the structured model of MCA of the sub-group of 29 children during the decrease of sevoflurane. From higher concentration (2 MAC) to 1 MAC (T10; steady state) and from 1 to 0.5 MAC (T20: steady state). Each point represents 1 min. The units of axes F1 and F2 are arbitrary. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 6 Position of the sub-group of 29 children on axis F1 (b) and axis F2 (a) of the structured model of the MCA during the decrease of sevoflurane concentration over time. T0: 2 MAC; T1 and T5: intermediate time; T10: steady state at 1 MAC; T15: intermediate time; T20: steady state at 0.5 MAC. Box plot (range; 10–90th centile; 25–75th centile; median). *vs T0: P<0.05; †vs T10 (1 MAC): P<0.05. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig A1 Examples of the EEG bispectra of nine children at the steady state of 1 MAC of sevoflurane. The children represented in the first column are all under 2 yr old, in the middle column between 6 and 7 yr old, and in the third column greater than 10 yr old. They are unordered examples of children in these age groups. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig A2 (a) Representation of the correlation between clinical variables (age, BIS, and end-tidal sevoflurane concentration) and children's coordinates on the two most dominant axes (F1 and F2) of the MCA model at the steady state 1 MAC sevoflurane (age-corrected) in all children. (b) Representation of the correlation between BIS values measured in all children at the steady state of 1 MAC sevoflurane (age-corrected) with age, and end-tidal sevoflurane concentration, respectively. British Journal of Anaesthesia 2005 94, 810-820DOI: (10.1093/bja/aei140) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions