Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−

Slides:



Advertisements
Similar presentations
Mitochondria localize to both the front and the rear of neutrophils.
Advertisements

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.
Osteosarcoma histology.
Leukemia involves the accumulation of ISP CD8+T-cells and blockages in B-cell development. Leukemia involves the accumulation of ISP CD8+T-cells and blockages.
The pathophysiological processes linked to kidney disease.
Abnormalities of the aortic arch in Hectd1opm/opm mutant embryos.
mTOR downregulation, but not autophagy, reduces VAP(P58S) aggregation.
Loss of RBP-J results in a reduction of segments due to total branch loss with age. Loss of RBP-J results in a reduction of segments due to total branch.
Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.
A Drosophila cell culture model to study VAP(P58S) aggregation.
OA and related amines modulate motility and length of schistosomula.
Discordance and similarity between humans with FA and FA mouse models.
X-ray radiographic images showing structural alterations of the joints that are most commonly affected by OA. (A) Normal and (A′) severely affected joint.
Concentration of biomarkers of haemostasis.
TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.
Hipk induces cell spreading.
Asj-2J mice show a progressive age-dependent increase in calcification in aorta, muzzle skin containing the dermal sheath of the vibrissae, kidney, spleen.
Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.
Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.
Behavioral test parameters.
Fluorescently labeled endocytic cargos enable imaging of caveolar endocytosis in the intact zebrafish intestine. Fluorescently labeled endocytic cargos.
Obesity affected the metabolic response to stroke.
Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.
Expression data confirm and extend existing knowledge
Factors affecting standardization of rodent impact TBI models.
Treatment of HCMT-CMs with bisoprolol.
Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.
Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.
Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.
Elevated expression of vegfaa in hemangiosarcoma.
Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs.
The effect of TDP-43A315T expression on dendrite spine development.
Fig. 6. STK35 KO mice show ovary defects.
The mutants exhibit congenital hypothyroidism.
Distribution and extent of expression.
Armadillos are the only natural host of leprosy, aside from humans.
The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.
Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.
TWEAK increases histone crotonylation in kidney tubular cells.
The effect of TDP-43A315T expression at the synapse.
Chronic phenytoin increases activity levels in Mecp2Null/Y mice.
Rgs16::GFP expression in pancreatic neoplasia.
Ang-1, ESE-1 and Tie-2 expression levels during teratogen-induced CDH
Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R mice with reduced interaction of Ltbp-4L and fibulin-4. Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R.
Otitis media in Edaraddswh/swh rats is associated with smaller auditory-tube submucosal glands (SMGs). Otitis media in Edaraddswh/swh rats is associated.
Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.
col22a1−/− mutant adults exhibit hemorrhages.
Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P
Increased expression of the drusen-associated genes (ApoE, ApoJ, ApoB and App) and Vegfa in the RPE/retina of Pgc-1α+/− mice under RD and HFD. (A) The.
Injection volume influences tumor architecture and desmoplastic response. Injection volume influences tumor architecture and desmoplastic response. (A)
Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A)
Food-additive exposure increases permeability in a human gut cell co-culture model. Food-additive exposure increases permeability in a human gut cell co-culture.
Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.
Optimized STZ treatment leads to specific cytotoxicity of insulin-producing cells. Optimized STZ treatment leads to specific cytotoxicity of insulin-producing.
Anti-epileptic drugs with Na+ channel blocking activity improve QTc in individuals with Rett syndrome. Anti-epileptic drugs with Na+ channel blocking activity.
MMP-9 expression. MMP-9 expression. (A) Lungs from M. tuberculosis-infected (H37Rv, 14 wpi, untreated) and age-matched uninfected (control) mice were harvested.
Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance.
Cross-validation between centres for inbred mice.
Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.
Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants.
Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats.
ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)
Peroxisome speeds were slower in patient and control cells.
Methods used to generate genetically modified pigs.
The vps13 mutants are hypersensitive to SDS but cell wall integrity is not compromised. The vps13 mutants are hypersensitive to SDS but cell wall integrity.
Summary of variabilities in hiPSC-CMs.
Effect of siRNA transfection on colony formation by Renca cells.
Graphical representation of pain levels versus time postinjury, annotated across control, persistently hypersensitive genotypes and diabetic conditions,
Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)
Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.
Presentation transcript:

Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. No visible atherosclerosis was seen in the aorta from WT pigs (A,D,G). ApoEm/m pigs had pathological fatty streak of the aorta (B,E,H). ApoE−/− pigs showed progressive atherosclerotic lesions in the luminal part of the arterial intima (C,F,I). Bin Fang et al. Dis. Model. Mech. 2018;11:dmm036632 © 2018. Published by The Company of Biologists Ltd