Delayed impairment of cerebral oxygenation after deep hypothermic circulatory arrest in children Eero J Pesonen, MD, Kaija I Peltola, MD, Reijo E Korpela,

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Delayed impairment of cerebral oxygenation after deep hypothermic circulatory arrest in children Eero J Pesonen, MD, Kaija I Peltola, MD, Reijo E Korpela, MD, Heikki I Sairanen, MD, Mauri A Leijala, MD, Kari O Raivio, MD, Sture H.M Andersson, MD The Annals of Thoracic Surgery Volume 67, Issue 6, Pages 1765-1770 (June 1999) DOI: 10.1016/S0003-4975(99)00320-3

Fig 1 Oxygen saturation of hemoglobin in arterial (closed triangles), mixed venous (open squares), and cerebral venous (closed squares) blood. 0 = preoperative level; 0b = before deep hypothermic circulatory arrest; and 2 minutes to 10 hours after deep hypothermic circulatory arrest. ∗p < 0.05 and ∗∗p < 0.01 versus 0. The Annals of Thoracic Surgery 1999 67, 1765-1770DOI: (10.1016/S0003-4975(99)00320-3)

Fig 2 Arterial plasma concentrations of hypoxanthine (white bars) and xanthine (black bars). 0 = preoperative level; 0b = before deep hypothermic circulatory arrest, and 2 minutes to 10 hours after deep hypothermic circulatory arrest. ∗∗p < 0.01 versus 0. The Annals of Thoracic Surgery 1999 67, 1765-1770DOI: (10.1016/S0003-4975(99)00320-3)

Fig 3 (A) Cerebral (ie, cerebral venous concentration − arterial concentration) and (B) whole body (ie, central venous concentration − arterial concentration) production of hypoxanthine. 0 = preoperative level; 0b = before deep hypothermic circulatory arrest, and 2 minutes to 10 hours after deep hypothermic circulatory arrest. ∗p < 0.05 and ∗∗p < 0.01, venous concentration versus arterial concentration. The Annals of Thoracic Surgery 1999 67, 1765-1770DOI: (10.1016/S0003-4975(99)00320-3)

Fig 4 Arterial plasma concentrations of lactoferrin. 0 = preoperative level; 0b = before deep hypothermic circulatory arrest, and 2 minutes to 10 hours after deep hypothermic circulatory arrest. ∗∗p < 0.01 versus 0. The Annals of Thoracic Surgery 1999 67, 1765-1770DOI: (10.1016/S0003-4975(99)00320-3)

Fig 5 Cerebral (ie, cerebral venous concentration − arterial concentration) production of lactoferrin. 0 = preoperative level; 0b = before deep hypothermic circulatory arrest, and 2 minutes to 10 hours after deep hypothermic circulatory arrest. ∗p < 0.05, venous concentration versus arterial concentration. The Annals of Thoracic Surgery 1999 67, 1765-1770DOI: (10.1016/S0003-4975(99)00320-3)