Volume 24, Issue 14, Pages R658-R659 (July 2014) Tumor Models: Tumor–Stroma Interactions Drive Neoplastic Transformation in Drosophila  Marco Milán  Current Biology  Volume 24, Issue 14, Pages R658-R659 (July 2014) DOI: 10.1016/j.cub.2014.05.074 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Tumor–stroma interactions in Drosophila epithelial tumors. A sketch depicting the spatial organization of epithelial (green) and mesenchymal (red) cells during normal development and in a neoplastic tumor. EGF receptor-expressing (green nuclei) transformed epithelial cells induce the expression of the mitogenic molecules Wingless and Dpp, which drive proliferation of epithelial and mesenchymal cells, respectively. The expression of Perlecan by the transformed cells is thought to potentiate Dpp signaling in mesenchymal cells. These cells support tumor growth and are required for epithelial transformation. Current Biology 2014 24, R658-R659DOI: (10.1016/j.cub.2014.05.074) Copyright © 2014 Elsevier Ltd Terms and Conditions