J. Sheppard Mondy, MD, J. Koudy Williams, DVM, Michael R

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Presentation transcript:

Structural determinants of lumen narrowing after angioplasty in atherosclerotic nonhuman primates J.Sheppard Mondy, MD, J.Koudy Williams, DVM, Michael R. Adams, DVM, Richard H. Dean, MD, Randolph L. Geary, MD Journal of Vascular Surgery Volume 26, Issue 5, Pages 875-883 (November 1997) DOI: 10.1016/S0741-5214(97)70103-4 Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Diagram of morphometry measurements made in each iliac artery ring. In the text, IELA refers to the area bounded by the internal elastic lamina (plaque/neointima and lumen). IA refers to plaque in uninjured arteries and plaque plus neointima in injured arteries. Medial area was not different in injured and uninjured arteries and was not included in subsequent analyses. Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Composite photomicrograph demonstrates uninjured iliac artery (A) and contralateral injured iliac artery (B) in an atherosclerotic cynomolgus monkey 1 month after balloon angioplasty. A complicated preexisting atherosclerotic plaque was fractured (arrowhead) and is seen underlying a significant accumulation of neointima. Sections were stained with Verhoeff–van Gieson stain and photographed at an original magnification of 40×. Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Composite photomicrograph demonstrates uninjured iliac artery (A) and contralateral injured iliac artery (B) in an atherosclerotic cynomolgus monkey 1 month after balloon angioplasty. A complicated preexisting atherosclerotic plaque was fractured (arrowhead) and is seen underlying a significant accumulation of neointima. Sections were stained with Verhoeff–van Gieson stain and photographed at an original magnification of 40×. Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Bar chart shows range of normalized LAs in 37 animals 1 month after iliac artery balloon injury. One third demonstrate significant loss of the initial gain in LA relative to the uninjured reference (LA ≤ 100% of uninjured control), whereas the remainder demonstrate some persistent lumen dilation. Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Scatter plots with regression lines for normalized LA compared with normalized IELA (A) and compared with normalized IA (B) of injured iliac arteries from 37 atherosclerotic cynomolgus monkeys. Lumen caliber and artery size are closely related (r = 0.72), whereas a poor correlation exists between lumen caliber and intimal mass (r = 0.10). Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Scatter plots with regression lines for normalized LA compared with normalized IELA (A) and compared with normalized IA (B) of injured iliac arteries from 37 atherosclerotic cynomolgus monkeys. Lumen caliber and artery size are closely related (r = 0.72), whereas a poor correlation exists between lumen caliber and intimal mass (r = 0.10). Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Bar chart compares normalized LA, IA, and IELA in arteries demonstrating restenosis (LA ≤ 100% of control) and those with no restenosis (LA ≥ 140% of control) after angioplasty. Both groups had a similar marked increase in intimal mass; however, final LA was mirrored by changes in artery wall size. *p < 0.001, restenosis vs no restenosis. Journal of Vascular Surgery 1997 26, 875-883DOI: (10.1016/S0741-5214(97)70103-4) Copyright © 1997 Society for Vascular Surgery and International Cociety for Cardiovascular Surgery, North American Chapter Terms and Conditions