Serum Protein Profiles in Myasthenia Gravis

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Presentation transcript:

Serum Protein Profiles in Myasthenia Gravis Chao Cheng, MD, PhD, Guoyong Wu, MD, Sai-Ching J. Yeung, MD, PhD, Rong Li, MD, PhD, Amos Ela Bella, MS, Jinzhuo Pang, MD, Fo-tian Zhong, MD, Honghe Luo, MD, Yanli Jin, MS, Jingxuan Pan, MD, PhD The Annals of Thoracic Surgery Volume 88, Issue 4, Pages 1118-1123 (October 2009) DOI: 10.1016/j.athoracsur.2009.05.032 Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Representative surface-enhanced laser desorption/ionization spectra comparison of serum between the myasthenia gravis (MG) patients and healthy control groups. In the MG sera, the proteins at M3951.23, M3969.56, M4168.94, and M4276.40 were decreased in comparison with the normal control sera. The x axis shows the molecular weight for each spectrum (mass/charge ratio values), and the y axis shows the relative intensity. The Annals of Thoracic Surgery 2009 88, 1118-1123DOI: (10.1016/j.athoracsur.2009.05.032) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 In the training data set, the Biomarker Pattern Software built the classification tree to classify myasthenia gravis patients or healthy controls. All the sera were categorized for a sensitivity and specificity of 100% and 89.3%, respectively, using peak at M4168.94 Da, M1122.57 Da as splitters. The Annals of Thoracic Surgery 2009 88, 1118-1123DOI: (10.1016/j.athoracsur.2009.05.032) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions