Expression of D-type cyclins during cerebellar development.

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Expression of D-type cyclins during cerebellar development. Expression of D-type cyclins during cerebellar development. (A-H) Distribution of cyclin D2 (A-D) and cyclin D1 (E-H) in the E15 cerebellum of wild-type (A,B,E,F) and Ccnd2–/– (C,D,G,H) mice. In wild-type mice, most Ccnd2-expressing cells are located in the SVZ (A,B), whereas cyclin D1-positive nuclei are packed in the VN (E,F). In mutant cerebella, cyclin D2 is absent (C,D), whereas cyclin D1 localization is unchanged (G,H). (I-P) Expression of the two cyclins in P0 wild-type (I,J,M,N) and Ccnd2–/– (K,L,O,P) cerebella. In wild-type mice, cyclin D2-positive cells are present in the PWM (I,J). Cyclin D1 immunolabelled nuclei are sparse in the PWM, but frequent in the GL (M,N). Both cyclins are expressed in the EGL. In mutant mice, cyclin D2 is absent (K,L), whereas the distribution of cyclin D1 is unaltered (O,P). (Q-X) A similar expression pattern of both proteins is observed at P4 in wild-type (Q,R,U,V) and Ccnd2–/– (S,T,W,X) cerebella. VN, ventricular neuroepithelium; SVZ, subventricular zone; EGL, external granular layer; ML, molecular layer; GL, granular layer; PWM, prospective white matter. Scale bars: 200 μm in A,C,E,G,I,K,M,O,Q,S,U,W; 100 μm in B,D,F,H,J,L,N,P,R,T,V,X. Ketty Leto et al. Development 2011;138:3463-3472 © 2011.